Before any study activities begin, the study doctor or designated person will provide information about the study in language that is easy to understand.

Written consent will be obtained from your legal guardian if required by local regulations, and your agreement (assent) will be obtained when applicable.

During the screening visit, your age, weight, and general health will be checked to determine if you meet the study requirements.

If you are female and have started menstruation or are 8 years of age or older, a pregnancy test will be performed within 24 hours before receiving the bowel cleansing medicine. The test must be negative to participate.

Your weight must be at least 10 kilograms. If you are between 1 and 4 years of age, your weight must be above the 10th percentile for your age according to standard growth charts.

You will be randomly assigned to receive one of two bowel cleansing medicines: either PLENVU or sodium picosulfate.

Both medicines are taken by mouth (oral route) and are used to clean the bowel before a colonoscopy, which is an examination of the large intestine using a camera.

Your legal guardian or caregiver will help maintain a take-home record that includes information about your general health and how you take the medicine.

You must be able to eat regular solid food or drink from a bottle or cup without breastfeeding during the study.

If you receive PLENVU, it will be prepared as a powder that is mixed with water to create a solution for drinking. The medicine contains ascorbic acid (vitamin C), sodium ascorbate, potassium chloride, sodium chloride (salts), and macrogol 3350 (a substance that helps clean the bowel).

If you receive sodium picosulfate, this medicine is also taken by mouth.

Your legal guardian or caregiver will record how well you follow the treatment instructions to measure compliance, which means how completely you take the medicine as directed.

The specific dosage, frequency, and duration of taking the medicine will be determined by the study doctor based on your age and weight.

You or your legal guardian will be asked to complete questionnaires about how easy or difficult it was to take the medicine (tolerability), how the medicine tasted (palatability), and your overall opinion about using the medicine (acceptability).

These questionnaires use a rating system called a Likert Scale, which allows you to indicate your level of agreement or disagreement with statements about your experience.

After taking the bowel cleansing medicine, you will undergo the colonoscopy examination as planned.

During the colonoscopy, the doctor performing the procedure will assess how well your bowel was cleaned using two different rating systems: the Boston Bowel Preparation Scale (BBPS) and the Harefield Cleansing Scale (HCS).

The doctor performing the colonoscopy will not know which bowel cleansing medicine you received (colonoscopist-blind), which helps ensure an unbiased assessment.

After the colonoscopy, you will be monitored for safety during a follow-up period.

If you are female and of childbearing potential, you must continue using a highly effective method of contraception (birth control with less than 1% failure rate per year) throughout this follow-up period.

If you are male and sexually active, you should use condoms throughout the follow-up period.

Your legal guardian or caregiver may need to accompany you to scheduled visits and provide information about your health using rating scales if required by local regulations or deemed necessary by the study doctor.