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XENON (133XE)

Clinical trials investigating “XENON (133XE)” are studying how it can be used in imaging to measure lung function before and after radiotherapy. The trial data focus on patients with lung and breast cancer, especially those at risk of radiation-related lung injury. The studies aim to assess functional and anatomical changes in the lungs.

Table of contents

Trial overview

This clinical trial is titled Pre- and post-treatment evaluation of lung function with Xenon-gas enhanced Dual-Energy CT-imaging in patients undergoing radiotherapy[1].

It is an interventional study, which means researchers actively give the study intervention and then measure what happens[1].

The trial is testing imaging with a gas mixture of 30 Vol% Xe in 70 Vol% O2 as a contrast agent, used together with Dual-Energy CT imaging to study the lungs[1].

Who is being studied

The trial includes patients with lung cancer and breast cancer who are scheduled to undergo radiotherapy[1].

The study also targets people at risk of radiation-induced lung injury, including radiation pneumonitis and radiation fibrosis[1].

Enrollment is planned for 40 participants, so this is a relatively small study focused on detailed imaging results[1].

What the trial is measuring

The main endpoint is to quantify radiotherapy-related changes in lung function by comparing pre-treatment and post-treatment ventilation maps[1].

Researchers will assess these changes in two ways: first by visual review of lung tissue and ventilation patterns, and second by numerical comparison of local ventilation metrics[1].

The study looks for areas that appear hypo- or hyperdense on colour-coded Xe-concentration maps, because these patterns may show how the lungs respond to treatment[1].

Phase and status

This trial is listed as Phase 4[1].

The status is Authorised, which means the study has been approved to proceed[1].

Phase 4 studies are often used to learn more about how a method performs in a more real-world setting after earlier development stages, although this trial is specifically focused on imaging results rather than treatment effect[1].

Why this research matters for patients

This research may help doctors and researchers better understand how radiotherapy affects the lungs in people treated for lung cancer or breast cancer[1].

By comparing lung images before and after treatment, the study may show where lung function changes happen and how strong those changes are[1].

That information can support future work on monitoring lung injury after radiotherapy, especially for problems such as pneumonitis and fibrosis[1].

Trial IDPhaseCondition studiedStatusEnrollment
2025-521559-22-00Phase 4Radiation-induced lung injury; lung and breast cancerAuthorised40

FAQ

  • What are clinical trials with XENON (133XE) trying to study? They are studying lung ventilation imaging before and after radiotherapy. The main goal is to see how lung function and lung structure change over time.
  • Who can join the trial? The trial is for patients with lung cancer or breast cancer who are scheduled to receive radiotherapy. It is focused on people whose lungs may be affected by treatment.
  • What phase is the trial? The study is listed as Phase 4. This means it is being done in a later stage of clinical research and is focused on real-world evaluation.
  • What outcomes are being measured? The main outcome is the change in lung ventilation maps before and after treatment. Researchers look at both visual changes and measured differences in ventilation patterns.
  • What condition is the trial related to? The trial is related to radiation-induced lung injury, including radiation pneumonitis and radiation fibrosis. These are lung problems that can happen after radiotherapy.

Ongoing Clinical Trials on XENON (133XE)

  • Evaluation of Lung Function Using Xenon Gas with CT Imaging in Lung and Breast Cancer Patients Receiving Radiotherapy

    Not yet recruiting

    4 1 1
    Investigated diseases:
    Investigated drugs:
    Belgium

Glossary

  • Radiotherapy: A treatment that uses radiation to kill cancer cells. It can also affect nearby healthy tissue, including the lungs.
  • Lung ventilation: How well air moves in and out of different parts of the lungs. Good ventilation means the lungs are working well in those areas.
  • Ventilation map: A picture that shows how air is distributed in the lungs. It helps doctors and researchers see which areas are working better or worse.
  • Dual-Energy CT: A type of CT scan that uses two energy levels to create more detailed images. In this trial, it is used with gas imaging to study the lungs.
  • Lung parenchyma: The working tissue of the lung where gas exchange happens. This is the part of the lung that can be affected by radiation.
  • Radiation pneumonitis: Inflammation of the lungs caused by radiation treatment. It can make breathing harder.
  • Radiation fibrosis: Scarring of the lung tissue after radiation treatment. Scarring can reduce how well the lungs work.
  • Qualitative analysis: A visual review of images by looking for changes and patterns. It is based on observation, not just numbers.
  • Quantitative analysis: A measurement-based review that uses numbers to compare results. It helps show how much change has happened.

References