Ly3541860

Clinical trials are studying Ly3541860 in adults with relapsing multiple sclerosis. These trials are designed to evaluate how well it works and to measure safety-related outcomes through MRI brain scans and other study checks. The available trial data focus on people with relapsing MS.

Table of Contents

Trial overview

The available trial data describe one Phase 2 interventional study of Ly3541860 in adults with relapsing multiple sclerosis.[1] The study was completed and enrolled 83 participants.[1]

Who participated

This study focused on adult participants with relapsing multiple sclerosis (RMS).[1] The trial data do not provide more detailed eligibility rules, such as age limits beyond adulthood or other medical requirements.[1]

What was measured

The main outcome was the cumulative number of new T1 gadolinium-enhancing lesions seen on MRI scans of the brain.[1] In simple terms, the study used brain imaging to count new areas that may show active disease.[1]

Study design and comparison

The brief summary says the study aimed to evaluate the efficacy of Ly3541860 versus placebo on the number of new T1 GdE MRI brain lesions in participants with RMS.[1] A placebo is a look-alike treatment used for comparison and does not contain the active study drug.[1]

The listed interventions included 0.9% sodium chloride, gadoteric acid, and Ly3541860 as a solution for injection.[1] The trial data do not explain the full treatment schedule or how these interventions were assigned.[1]

What the trial data show

From the provided data, the key point is that researchers studied Ly3541860 in a completed Phase 2 trial for relapsing multiple sclerosis.[1] The main focus was on MRI brain lesions, which are used to track disease activity in MS.[1] No outcome results are included in the source data, so the trial record here tells us about the study plan and target group, not the final findings.[1]

Trial ID Phase Condition studied Status Enrollment
2023-503289-22-00 Phase 2 Relapsing Multiple Sclerosis Completed 83

Ongoing Clinical Trials on Ly3541860

  • Study of LY3541860 and Meglumine Gadoterate for Adults with Relapsing Multiple Sclerosis

    Not recruiting

    2 1 1
    Investigated diseases:
    France Germany Italy Latvia Lithuania Poland +1

Glossary

  • Relapsing multiple sclerosis (RMS): A form of multiple sclerosis where symptoms get worse in episodes, called relapses, and may improve between episodes.
  • Adult participants: People who are grown up and eligible to join the study.
  • Phase 2: A mid-stage clinical trial that looks at whether a treatment may work and continues to collect safety information.
  • Interventional study: A study where participants receive a treatment or placebo so researchers can compare outcomes.
  • Placebo: A look-alike treatment with no active study drug, used for comparison.
  • MRI: Magnetic resonance imaging, a scan that makes detailed pictures of the inside of the body, including the brain.
  • Lesion: An area of damage or change seen on a scan.
  • Gadolinium-enhancing lesion: A lesion that becomes easier to see on MRI after contrast dye is given, which can show active disease.
  • T1 lesion: A type of MRI finding used to help measure disease activity in the brain.
  • Enrollment: The number of people who joined the study.

References

  1. https://clinicaltrials.gov/study/2023-503289-22-00