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Argon

Clinical trials are investigating Argon in people resuscitated after cardiac arrest. The main goal is to see whether Argon mixed with oxygen can help protect the brain after this emergency. These studies focus on safety and treatment effect in adults with out-of-hospital cardiac arrest.

Table of Contents

Trial overview

The main clinical trial in the source data is the CardioPulmonary resuscitation with Argon (CPAr) trial, which is an interventional study in Phase 2.[1] It is authorised and plans to enroll 120 people.[1] The study is looking at whether Argon given with oxygen can help after cardiac arrest.[1]

Who is being studied

This trial focuses on patients who have been resuscitated after out-of-hospital cardiac arrest, which means the heart stopped outside a hospital and emergency care was needed.[1] The condition being studied is cardiac arrest, with special attention to possible brain injury after the event.[1]

Treatment being tested

The study tests an inhaled gas mixture of Argon/Oxygen at 70% Argon and 30% oxygen.[1] The comparison treatment is oxygen alone at 30% in inhalation gas form.[1] The brief summary says the gas is given with an experimental ventilator that was specially modified to allow Argon/Oxygen ventilation.[1]

Trial phase and design

The CPAr trial is a Phase 2 study.[1] Phase 2 trials usually look more closely at whether a treatment may work in a specific group of patients while continuing safety checks, although the source data does not give extra detail beyond the phase number.[1] This study is also described as interventional, meaning researchers actively give the study treatment and compare outcomes.[1]

What researchers are measuring

The main outcome is the 48-hour serum neuron specific enolase (NSE) concentration.[1] NSE is a blood marker that researchers use to help evaluate possible nerve cell or brain injury.[1] In this study, the NSE result is being used to judge the activity of Argon in preserving neurons, which are the cells in the brain and nervous system.[1]

Why this study matters

The trial is designed to find out whether Argon mixed with oxygen may reduce post-cardiac arrest neurological injury, meaning brain damage that can happen after the heart starts again.[1] Because the study is being done soon after resuscitation, it targets a very serious emergency situation where protecting the brain is important.[1] The available data show one focused study, so the current research picture is narrow but clinically important.[1]

Trial ID Phase Condition studied Status Enrollment Main endpoint
NCT05482945 Phase 2 Cardiac arrest Authorised 120 48 h Serum Neuron Specific Enolase (NSE) concentration

FAQ

  • What is being studied in Argon clinical trials? The trial is studying an Argon and oxygen mixture given by inhalation after cardiac arrest. Researchers want to see if it can reduce brain injury after resuscitation.
  • Who can take part in these trials? The study is for patients who have been resuscitated after out-of-hospital cardiac arrest. It focuses on people in the emergency setting after this event.
  • What phase is the Argon trial? The trial is in Phase 2. This phase usually looks at whether a treatment may work and continues to assess safety.
  • What condition is the trial studying? The trial is studying cardiac arrest. More specifically, it looks at neurological injury after resuscitation from out-of-hospital cardiac arrest.
  • What outcome is being measured? The main outcome is serum neuron specific enolase, or NSE, at 48 hours. NSE is a blood marker that can help show possible brain cell injury.

Ongoing Clinical Trials on Argon

  • Study on the Safety of Argon and Oxygen Ventilation for Patients Resuscitated from Cardiac Arrest

    Not yet recruiting

    2 1 1 1
    Investigated drugs:
    Italy

Glossary

  • Cardiac arrest: A sudden stop of the heart. This is an emergency because the body and brain do not get enough blood and oxygen.
  • Out-of-hospital cardiac arrest: A cardiac arrest that happens outside a hospital, such as at home or in public.
  • Resuscitated: Brought back after the heart has stopped, usually with emergency treatment.
  • Interventional study: A study where researchers give a treatment or procedure and then measure the results.
  • Phase 2: A mid-stage clinical trial that looks more closely at whether a treatment may work and continues safety checks.
  • Inhalation gas: A gas breathed in through a device or ventilator.
  • Neurological injury: Damage to the brain or nervous system.
  • Neuron Specific Enolase (NSE): A blood test marker that can help doctors and researchers estimate possible injury to nerve cells, especially in the brain.
  • Primary outcome: The main result the researchers plan to measure in a trial.
  • Enrollment: The number of people planned to take part in the study.

References