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A/Wisconsin/67/2022 (H1N1)Pdm09-Like Strain (A/Georgia/12/2022 Cvr-167)

This article discusses the use of the A/Wisconsin/67/2022 (H1N1)Pdm09-Like Strain (A/Georgia/12/2022 CVR-167) in clinical trials for influenza vaccines. This strain is one of the components in the Flucelvax Tetra vaccine, which is being studied to assess its safety, effectiveness, and long-term outcomes in preventing influenza.

Table of Contents

What is A/WISCONSIN/67/2022 (H1N1)PDM09-LIKE STRAIN?

A/WISCONSIN/67/2022 (H1N1)PDM09-LIKE STRAIN (A/GEORGIA/12/2022 CVR-167) is a component of the influenza vaccine known as Flucelvax Tetra[1]. This strain is specifically designed to protect against a type of influenza A virus, which is one of the main types of flu viruses that circulate among humans. The term “H1N1” refers to specific proteins on the surface of the virus, which help identify it[1].

Purpose of the Vaccine

The primary purpose of this vaccine component is to prevent influenza, commonly known as the flu. Influenza is a contagious respiratory illness that can cause mild to severe illness, and in some cases, can lead to hospitalization or even death, especially in high-risk groups[1].

Vaccine Composition

Flucelvax Tetra, which contains the A/WISCONSIN/67/2022 (H1N1)PDM09-LIKE STRAIN, is a quadrivalent vaccine. This means it protects against four different flu viruses[1]. The vaccine includes:

  • A/WISCONSIN/67/2022 (H1N1)PDM09-LIKE STRAIN (A/GEORGIA/12/2022 CVR-167): This is the strain we’re focusing on, which protects against a specific type of H1N1 influenza A virus[1].
  • A/DARWIN/6/2021(H3N2)-LIKE STRAIN: This protects against another type of influenza A virus[1].
  • B/AUSTRIA/1359417/2021-LIKE STRAIN: This protects against one lineage of influenza B virus[1].
  • B/PHUKET/3073/2013-LIKE VIRUS: This protects against another lineage of influenza B virus[1].

How is it Administered?

The Flucelvax Tetra vaccine, which contains the A/WISCONSIN/67/2022 (H1N1)PDM09-LIKE STRAIN, is administered via intramuscular injection. This means the vaccine is injected directly into a muscle, typically in the upper arm for adults[1].

Dosage Information

The maximum daily dose and maximum total dose of the Flucelvax Tetra vaccine is 0.5 ml[1]. This single dose contains all four strains of the influenza virus, including the A/WISCONSIN/67/2022 (H1N1)PDM09-LIKE STRAIN. The vaccine is typically given once per flu season, which is why the maximum treatment period is listed as 1 day[1].

Benefits of the Vaccine

The inclusion of the A/WISCONSIN/67/2022 (H1N1)PDM09-LIKE STRAIN in the Flucelvax Tetra vaccine offers several benefits:

  1. Protection against current strains: This strain is selected based on surveillance data to match the H1N1 viruses expected to circulate during the flu season[1].
  2. Broad coverage: As part of a quadrivalent vaccine, it helps provide protection against multiple flu strains[1].
  3. Reduced risk of flu-related complications: By preventing influenza infection, it can help reduce the risk of flu-related complications, hospitalizations, and deaths[1].
  4. Cell-based production: Flucelvax Tetra is prepared in cell cultures, which can potentially offer advantages in terms of production speed and avoiding egg-based allergies[1].

It’s important to note that while this vaccine component is designed to provide protection against specific flu strains, the effectiveness can vary from season to season and person to person. However, vaccination remains one of the most effective ways to prevent flu and its potential complications[1].

Aspect Details
Vaccine Name Flucelvax Tetra
Strain Studied A/Wisconsin/67/2022 (H1N1)Pdm09-Like Strain (A/Georgia/12/2022 CVR-167)
Vaccine Type Influenza vaccine (surface antigen, inactivated, prepared in cell cultures)
Administration Method Intramuscular injection
Dosage 0.5 ml
Other Strains in Vaccine B/Phuket/3073/2013-Like Virus, B/Austria/1359417/2021-Like Strain, A/Darwin/6/2021(H3N2)-Like Strain
Marketing Authorization EU/1/18/1326/003
Manufacturer Seqirus Netherlands B.V.

FAQ

  • What is the A/Wisconsin/67/2022 (H1N1)Pdm09-Like Strain? The A/Wisconsin/67/2022 (H1N1)Pdm09-Like Strain (A/Georgia/12/2022 CVR-167) is a specific influenza virus strain used in the Flucelvax Tetra vaccine. It's one of four strains included in the vaccine to protect against different types of influenza viruses.
  • What is Flucelvax Tetra? Flucelvax Tetra is an influenza vaccine that contains four different influenza virus strains, including the A/Wisconsin/67/2022 (H1N1)Pdm09-Like Strain. It's designed to provide protection against multiple types of influenza viruses in a single vaccine.
  • How is the vaccine administered? The Flucelvax Tetra vaccine is administered through intramuscular injection. This means it's injected directly into a muscle, typically in the upper arm for adults.
  • What is the dosage of the vaccine? The maximum daily dose and maximum total dose of the Flucelvax Tetra vaccine is 0.5 ml. This is typically given as a single injection.
  • Are there any specific patient groups being studied in the clinical trials? While the provided information doesn't specify particular patient groups for this strain, influenza vaccines are generally studied in various age groups and populations to ensure their safety and effectiveness for widespread use.

Ongoing Clinical Trials on A/Wisconsin/67/2022 (H1N1)Pdm09-Like Strain (A/Georgia/12/2022 Cvr-167)

  • Study of Influenza Vaccine Effects on Immune Response in the Nose and Airways in Adults Seeking Protection Against Seasonal Flu

    Not recruiting

    3 1 1 1
    Investigated drugs:
    France

  • Study on Long-Term Safety and Effectiveness of Ofatumumab for Patients with Relapsing Multiple Sclerosis

    Not recruiting

    3 1 1 1
    Investigated drugs:
    Austria Belgium Bulgaria Croatia Czechia Denmark +15

Glossary

  • Influenza vaccine: A vaccine designed to protect against infection by influenza viruses. It typically contains inactivated or weakened forms of several influenza virus strains.
  • Intramuscular injection: A method of administering medication by inserting the needle directly into a muscle. For vaccines, this is often done in the upper arm or thigh.
  • Strain: In the context of viruses, a strain refers to a genetic variant or subtype of a virus. Different strains of the same virus may have slightly different characteristics.
  • Inactivated vaccine: A type of vaccine that uses viruses that have been killed or inactivated, so they cannot cause disease but can still stimulate an immune response.
  • Surface antigen: A molecule on the surface of a cell or virus that can be recognized by the immune system. In vaccines, these are often used to stimulate an immune response.
  • Cell culture: A method of growing cells in a controlled laboratory environment, often used in vaccine production to grow viruses.

References

  1. http://clinicaltrials.eu/trial/study-on-long-term-safety-and-effectiveness-of-ofatumumab-for-patients-with-relapsing-multiple-sclerosis/