Ongoing Clinical Trials for Thyroid Disorder
There is currently 1 ongoing clinical trial for patients with thyroid disorder. This trial is investigating whether using a special imaging dye during thyroid surgery can help prevent complications related to low calcium levels after the procedure.
Clinical trial locations
Study of Indocyanine Green Angiography to Prevent Hypoparathyroidism in Patients Undergoing Total Thyroid Removal
This trial is being conducted in France and focuses on preventing complications after complete thyroid removal surgery. The study investigates whether using a special imaging technique during surgery can help protect small glands near the thyroid called parathyroid glands, which are essential for maintaining normal calcium levels in the body.
Who can participate:
This trial is open to adults between 18 and 65 years old who need to have their entire thyroid gland removed. You must be covered by health insurance and able to understand and agree to the study procedures. Both men and women can participate.
Who cannot participate:
You cannot join this study if you are younger than 18 or older than 65, have had previous thyroid surgery, or already have low calcium levels before surgery. The trial excludes people who are allergic to indocyanine green (the imaging dye used), women who are pregnant or breastfeeding, and those with kidney disease or parathyroid gland disorders. You also cannot participate if you are taking medications that affect calcium levels or have serious heart, liver, or blood disorders.
What the trial involves:
The main goal of this study is to determine whether using indocyanine green during surgery can reduce the risk of developing low calcium levels after thyroid removal. During the operation, some patients will receive an injection of this special dye, which helps surgeons see blood vessels and the parathyroid glands more clearly under special infrared light. This may help surgeons better preserve these important glands during the procedure.
After surgery, your medical team will closely monitor your calcium levels for up to 6 months. Blood tests will be performed in the first 48 hours after surgery, at day 8, and then at 1 month and 6 months. Doctors will check how well your parathyroid glands are working and watch for any signs of low calcium, which can cause muscle spasms, numbness, or tingling sensations.
Investigational approach:
The trial uses indocyanine green, a medical dye that glows under special infrared light, making it easier for surgeons to locate and preserve the parathyroid glands during surgery. This dye is injected into the bloodstream at a dose of up to 0.5 milligrams per kilogram of body weight. The study compares outcomes between patients who receive this imaging assistance and those who undergo standard thyroid surgery without it. Blood albumin levels are also measured to help doctors correctly interpret calcium levels throughout the study period.
Summary
Currently, there is one active clinical trial available for patients requiring total thyroid removal. This study, located in France, focuses on preventing a common complication of thyroid surgery: low calcium levels caused by damage to the parathyroid glands. The trial tests whether advanced imaging technology using indocyanine green can help surgeons better identify and protect these small but important glands during surgery. This research is particularly relevant for adults scheduled for complete thyroid removal who want to minimize their risk of post-surgical complications affecting calcium regulation in the body.