In short
There are currently 3 ongoing clinical trials investigating different approaches to improve outcomes for patients undergoing pulmonary resection surgery. These studies focus on optimizing oxygen delivery during surgery, improving post-operative sleep quality and recovery in elderly patients, and reducing pain medication requirements through alternative treatments.
Clinical trial locations
- Belgium
- Spain
Evaluation of Oxygen Administration Methods During One-Lung Ventilation in Patients Undergoing Lung Resection Surgery
This trial, conducted in Spain, examines different methods of delivering oxygen during surgery when a portion of the lung needs to be removed. During this type of operation, doctors temporarily stop ventilating one lung to allow better surgical access, a technique called one-lung ventilation.
Who can participate: Patients must be at least 18 years old and scheduled for lung resection surgery requiring a special breathing tube that separates the lungs. Participants must be legally competent, able to understand and sign the informed consent form, and willing to take part in the study voluntarily.
Who cannot participate: The trial excludes patients younger than 18 or older than 65, those who are pregnant or breastfeeding, and anyone with a history of previous chest surgery. People with severe lung diseases such as severe asthma or chronic obstructive pulmonary disease, serious heart conditions, or a Body Mass Index over 35 cannot join. The study also excludes those with blood clotting problems, active infections, neuromuscular diseases, or weakened immune systems. Emergency surgery cases and patients who have participated in another clinical trial within the past 30 days are not eligible.
What the trial investigates: The research compares three different techniques for giving oxygen to the lung that is not being operated on during surgery. The medical team will monitor how well patients breathe after surgery, their overall recovery, and how long they need to stay in the hospital. Blood and lung fluid samples will be collected to analyze markers of inflammation and how the body responds to the surgery.
Investigational approaches: The study uses two main oxygen delivery methods: continuous oxygen therapy to maintain proper oxygenation of lung tissue, and positive airway pressure, which involves applying gentle air pressure to keep airways open while delivering oxygen. Both approaches aim to prevent complications when only one lung is being mechanically ventilated.
Study of Dexmedetomidine Effects on Sleep Quality and Fatigue After Major Surgery in Elderly Patients Aged 60 and Older
This Belgian study focuses on elderly patients aged 60 and above undergoing thoracoscopic lung resection surgery, a minimally invasive procedure performed through small incisions using a special camera. The research examines whether giving a medication called dexmedetomidine during the first night after surgery can improve sleep quality and reduce tiredness.
Who can participate: Patients must be 60 years of age or older and scheduled for thoracoscopic lung resection surgery. Both men and women can participate, and they must be willing to receive medication during the first night after surgery and have their sleep quality monitored.
Who cannot participate: The trial excludes anyone under 60 years old or not scheduled for this specific type of surgery. People with known allergies to dexmedetomidine, severe heart conditions affecting heart rate or blood pressure, or a history of sleep disorders cannot join. Those currently taking sleep medications, with mental health conditions that could affect sleep patterns, or with liver or kidney problems are also excluded. Pregnant or breastfeeding women, people who cannot provide informed consent, those with a history of substance abuse within the past year, and anyone currently in another clinical trial are not eligible.
What the trial investigates: The study will monitor various aspects of recovery including sleep patterns, physical strength, tiredness levels, and overall well-being. Researchers will use questionnaires and physical tests to measure how well patients recover. They will also track brain activity during sleep using a wearable device and measure body chemicals that indicate healing progress.
Investigational drug: Dexmedetomidine is a sedative medication that helps patients relax and sleep by affecting certain natural chemicals in the brain. It is commonly used in intensive care units and during surgical procedures. The medication is given through an intravenous line during the night after surgery to help elderly patients sleep better, which may improve their overall recovery.
Study on Lidocaine and Magnesium Sulfate for Patients Undergoing Lung Surgery with Video-Assisted Thoracic Surgery (VATS)
This Spanish trial investigates whether two medications, lidocaine and magnesium sulfate, can help reduce the need for morphine in the first 24 hours after lung resection surgery performed using Video-Assisted Thoracic Surgery. This surgical approach uses a camera and instruments inserted through small incisions in the chest.
Who can participate: Patients must be 18 years of age or older and scheduled to have surgery to remove a lung tumor using video-assisted thoracoscopy. They must provide consent to participate in the study and be able, in the investigator's opinion, to follow all trial requirements.
Who cannot participate: The trial excludes patients not undergoing Video-Assisted Thoracic Surgery, those outside the specified age range, and individuals who belong to vulnerable populations requiring special protection or care.
What the trial investigates: The study aims to determine if giving lidocaine and magnesium sulfate intravenously during surgery can decrease the amount of morphine needed afterward. Researchers will monitor morphine consumption in the first 24 hours after surgery, pain levels both at rest and during deep breathing, and various complications that may arise. Long-term follow-up includes checking for lung cancer recurrences, quality of life, cognitive function, lung capacity, and potential hospital readmissions.
Investigational drugs: Lidocaine is a medication used to numb tissue in a specific area and works by blocking nerve impulse conduction. Magnesium sulfate is a mineral that helps relax muscles and nerves by influencing calcium flow and neurotransmitter release. Both are administered intravenously during surgery to potentially reduce pain and lower the need for morphine in the postoperative period.
Summary
The three ongoing clinical trials for pulmonary resection surgery demonstrate different approaches to improving patient outcomes. Spain hosts two of the three trials, both addressing different aspects of surgical care: one focusing on oxygen delivery techniques during one-lung ventilation and another examining pain management through lidocaine and magnesium sulfate. Belgium contributes one trial specifically targeting elderly patients aged 60 and older, investigating sleep quality and recovery through dexmedetomidine administration.
The trials collectively address important aspects of surgical care including respiratory support during surgery, post-operative pain management, and recovery quality in elderly patients. Each study uses different methodologies, from comparing oxygen delivery techniques to testing medications that may reduce the need for morphine or improve sleep quality after surgery. These investigations reflect the ongoing effort to optimize surgical procedures and recovery processes for patients undergoing lung resection.
