Ongoing Clinical Trials Related to Oesophagectomy
Currently, there is 1 ongoing clinical trial investigating nutritional support strategies for patients undergoing oesophagectomy. This trial is examining how different methods of providing nutrition after surgery may help prevent muscle loss during recovery.
Clinical trial locations
Study on Nutrition Methods and Muscle Loss After Esophagectomy Using SmofKabiven and Drug Combination for Patients Recovering from Esophageal Surgery
This clinical trial is investigating how different nutritional approaches affect muscle loss following surgery. The procedure removes part or all of the esophagus, the tube that carries food from the mouth to the stomach, and is often necessary for patients with certain esophageal conditions.
Main inclusion criteria:
- Must be scheduled for a planned surgical removal of part or all of the esophagus
- Surgery must include one of several reconstructive procedures, such as using the stomach, duodenum, or colon to restore digestive function
- Must be able to receive nutrition either through a feeding tube into the digestive tract (enteral nutrition) or directly into the bloodstream (TPN – Total Parenteral Nutrition)
- Must be at least 18 years old
- Both males and females can participate
Main exclusion criteria:
- Patients who have previously undergone this type of surgery
- Patients outside the specified age range
- Vulnerable populations who might be at higher risk of harm or exploitation
Focus and goal of the trial:
The study aims to understand how the route of nutrition impacts cachexia, a condition of severe muscle wasting that can occur after major surgery. Participants will have CT-scans performed before surgery and 10 days after to measure any changes in muscle size. The trial will compare how effective different nutritional strategies are in preventing muscle loss, potentially improving recovery and overall outcomes for patients undergoing this type of surgery.
Investigational approach:
The study uses SmofKabiven emulsion for infusion, a specialized mixture of nutrients delivered directly into the bloodstream. This mixture contains amino acids (the building blocks of proteins), oils rich in omega-3 fatty acids, glucose, and essential electrolytes. Participants will receive either the SmofKabiven emulsion or a placebo, allowing researchers to compare the effectiveness of this nutritional therapy in maintaining muscle mass during the 10-day post-surgery monitoring period.
Summary
Currently, only one clinical trial is actively recruiting patients undergoing oesophagectomy. This trial, conducted in Denmark, focuses specifically on nutritional support strategies to prevent muscle wasting after surgery. The research emphasizes the importance of optimizing nutrition delivery methods during the critical recovery period following this major surgical procedure. The trial is investigating specialized nutritional formulations delivered through different routes to determine the most effective approach for preserving muscle mass and potentially improving patient outcomes.
