This clinical trial is focused on understanding how different ways of providing nutrition affect muscle loss after a surgery called oesophagectomy. An oesophagectomy is a procedure where part or all of the esophagus, the tube that carries food from the mouth to the stomach, is removed. This surgery is often necessary for patients with certain conditions affecting the esophagus. The study will use a treatment called SmofKabiven emulsion for infusion, which is a special mixture of nutrients given directly into the bloodstream. This mixture includes various amino acids, which are the building blocks of proteins, as well as oils rich in omega-3 fatty acids, and other essential nutrients like glucose and electrolytes.
The purpose of the study is to explore how the route of nutrition impacts a condition known as cachexia, which is a type of severe muscle wasting that can occur after major surgeries like oesophagectomy. Participants in the study will receive either the SmofKabiven emulsion or a placebo. The study will observe changes in muscle size using a method called CT-scan, which is a type of imaging that allows doctors to see detailed pictures of the inside of the body. This will be done before the surgery and again 10 days after the surgery to assess any differences in muscle size.
The trial will follow participants over a period of time to gather information on how effective the SmofKabiven emulsion is in preventing muscle loss compared to other forms of nutrition. The study aims to provide valuable insights into the best nutritional strategies for patients undergoing oesophagectomy, potentially improving recovery and overall outcomes for these patients.
Denmark 
