Rare diseases
Investigational molecules
Locations
Recruiting trials first
3 clinical trials in this condition
Germany
The NetherlandsGermanyIn short
There is currently 1 ongoing clinical trial for patients with Malignant Neoplasm Of Unknown Primary Site (Also known as: Carcinoma of Unknown Primary, CUP). This trial is investigating a new imaging technique to help locate the original site of the cancer when it cannot be identified through standard testing. The study is taking place in the Netherlands and is using an advanced PET-CT scan with a special imaging agent.
This clinical trial is designed for patients who have been diagnosed with cancer that has spread to other parts of the body, but where doctors have been unable to find where the cancer originally started. This condition is called Carcinoma of Unknown Primary, or CUP. The study will use a special imaging technique to try to locate the primary tumor.
Who can participate:
Who cannot participate:
What the trial involves:
The main goal of this study is to determine how effective a new imaging technique called [18F]F-FAPI PET-CT is at identifying the primary tumor in patients with CUP. The trial uses a special imaging agent called [18F]-AlF-FAPI-74, which is designed to highlight cancer cells during the scanning process. This agent works by binding to a protein called fibroblast activation protein, which is often found in higher amounts in cancerous tissues.
Participants will receive an injection of the [18F]-AlF-FAPI-74 solution into a vein, followed by a PET-CT scan. This scan combines two imaging techniques to provide detailed pictures of the inside of the body. The doctors will then assess whether this method can accurately detect the primary tumor that other standard tests have not been able to find.
The investigational drug:
The study uses [18F]F-FAPI, a special imaging agent that helps doctors see where cancer cells might be located. It is administered through the PET-CT scan process and is classified as a diagnostic radiopharmaceutical. This means it is used for imaging purposes rather than as a treatment. The agent makes it easier for doctors to see potential cancer sites on the scan by highlighting areas where cancer cells may be present.
The study is expected to continue until 2026, with recruitment starting in 2024. This trial takes place in the Netherlands.
Currently, there is one active clinical trial available for patients with Malignant Neoplasm Of Unknown Primary Site. The trial is focused on improving diagnostic capabilities using advanced imaging technology. It is taking place in the Netherlands and is specifically designed for patients whose primary cancer site remains unidentified after standard diagnostic procedures.
The study investigates the use of [18F]F-FAPI PET-CT scanning, which represents a novel approach to locating the original tumor site in patients with Carcinoma of Unknown Primary. This diagnostic imaging technique may help doctors provide more targeted care by identifying where the cancer first began, which has been difficult to determine with conventional testing methods.
Patients interested in participating should meet specific eligibility criteria, including being 18 years or older and having undergone standard diagnostic testing without success in locating the primary tumor. The trial offers an opportunity to access an innovative imaging technology that is not yet widely available outside of research settings.
This guide is here to help you understand the condition. It does not replace a conversation with your doctor, who knows your situation best.
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