Hyperhidrosis

Hyperhidrosis

Hyperhidrosis is a condition where your body sweats much more than it needs to stay cool. This excessive sweating can soak through your clothes, disrupt your daily activities, and cause emotional distress, but there are many treatments available to help you manage it.

Table of contents

What is hyperhidrosis?

Hyperhidrosis is a medical condition that causes excessive sweating beyond what your body needs to regulate its temperature[1]. While sweating is a normal and healthy response to heat or physical activity, people with hyperhidrosis sweat heavily even when they are at rest, in cold temperatures, or at times when sweating would not normally be expected[1][3].

This condition is more common than many people think. Around 3 to 4 percent of the population experiences hyperhidrosis, meaning that millions of people worldwide are affected by this condition[2][3]. Despite its prevalence, less than half of those affected discuss the problem with their physician[13].

Types of hyperhidrosis

There are two main types of hyperhidrosis, and understanding which type you have is important because treatment approaches can differ significantly between them[2].

Primary focal hyperhidrosis is the most common type, affecting more than 90 percent of people with excessive sweating[8]. This type usually affects specific areas of the body, such as the hands, feet, underarms, or face. It typically begins in childhood or adolescence, often before age 25[12]. The exact cause of primary hyperhidrosis is unknown, but it is believed to involve overactive sweat glands, possibly influenced by genetic factors. Many people with this condition have a family history of excessive sweating[2][13].

Secondary generalized hyperhidrosis occurs as a result of an underlying medical condition or as a side effect of medication[1][2]. This type can affect larger areas of the body or the entire body. Medical conditions that can cause secondary hyperhidrosis include diabetes, thyroid problems, menopause, Parkinson’s disease, infections, and certain types of cancer[3][8]. Medications such as antidepressants, painkillers, and certain blood pressure medications can also trigger excessive sweating[2]. Unlike primary hyperhidrosis, secondary hyperhidrosis may cause you to sweat while sleeping[12].

Signs and symptoms

The main symptom of hyperhidrosis is heavy, excessive sweating that goes beyond what is needed for body temperature regulation[1]. You may sweat so much that moisture soaks through your clothes or drips from your hands[1][3].

People with hyperhidrosis may experience visible droplets of sweat dripping from their fingertips or palms, sweat that makes socks and shoes moist, or sweat from the armpits that drips down the body[3]. The sweating usually occurs on both sides of the body and typically happens at least once a week during waking hours[1][13].

Over time, hyperhidrosis can lead to additional symptoms. When sweat irritates your skin, you may experience itching and inflammation. Body odor can develop when bacteria on your skin mixes with sweat. On the feet, you may notice cracked or peeling skin[12].

What causes excessive sweating?

Sweating is controlled by your nervous system, which sends signals to your sweat glands to produce moisture that cools your body when you get hot[12]. You also sweat when you feel nervous or stressed. In hyperhidrosis, these sweat glands become overactive[12].

The body has two to four million sweat glands distributed throughout, with the majority being eccrine glands. These glands secrete a clear, odorless fluid that helps control body temperature through evaporation[6]. In people with hyperhidrosis, the eccrine glands activate and produce sweat even without the usual triggers of heat or physical activity[12].

The exact cause of primary hyperhidrosis remains unknown despite extensive research[2]. However, it is thought to involve a problem with the nervous system’s control of sweating rather than a problem with the sweat glands themselves. The condition may be due to either overactivity of the sympathetic nervous system or abnormal processing of emotional signals in the brain[5]. Genetic factors are believed to play a role, as the condition often runs in families, with one-third to one-half of patients having a family history of hyperhidrosis[2][13].

Secondary hyperhidrosis has more identifiable causes. Lifestyle factors such as stress, diet, and caffeine intake can trigger or worsen symptoms[3]. Certain medications, including dopamine agonists, antidepressants, and insulin, are known to cause excessive sweating as a side effect[2].

Where does hyperhidrosis affect the body?

Sweat comes from eccrine glands located throughout the skin, but you have the highest concentration of these glands in certain areas[12]. Primary focal hyperhidrosis most commonly affects the armpits (called axillary hyperhidrosis), the palms of the hands (palmar hyperhidrosis), the soles of the feet (plantar hyperhidrosis), and the forehead and cheeks (craniofacial hyperhidrosis)[2][12]. The palms of the hands are the most common location for excessive sweating[12].

In more than half of cases, primary hyperhidrosis affects the underarms[8]. Many people experience excessive sweating in more than one area of the body, with hands and feet being the most common combination[15].

Impact on daily life

Hyperhidrosis can significantly affect quality of life, resulting in social, work, and emotional difficulties[2]. More than one-third of people with underarm hyperhidrosis report that the condition is barely tolerable or completely intolerable, and it nearly always interferes with daily activities[13].

The condition can disrupt your daily routine and cause emotional distress. Many people feel embarrassed when they sweat and may avoid social situations or physical contact with others[1][8]. Some individuals avoid certain activities or hobbies, including reading print materials due to difficulty handling sweat-soaked pages[18]. The condition can harm self-esteem, confidence, and career advancement, with some people needing to change clothing several times a day[12].

For young people, excessive sweating may first become noticeable when moist palms begin to interfere with school and social activities[15]. If hyperhidrosis affects your mental health, it is important to reach out to a healthcare provider to help manage your symptoms and to a mental health professional to help you cope with how you feel about your body[12].

How is hyperhidrosis diagnosed?

Diagnosing hyperhidrosis typically begins with your healthcare provider taking a detailed medical history and asking about your sweating patterns and symptoms[8][9]. You may also need a physical examination.

To diagnose primary hyperhidrosis, your symptoms should meet certain criteria. These include focal, visible, excessive sweating for longer than six months without an apparent cause, and at least two of the following: sweating that is bilateral and symmetric, impairs daily activities, occurs at least once per week, starts before age 25, has a family history, or stops during sleep[13].

Your healthcare provider may use the Hyperhidrosis Disease Severity Scale, a validated survey that measures how much sweating affects your quality of life[13]. This scale helps determine the severity of your condition and guides treatment decisions.

If your doctor suspects that your sweating is caused by another medical condition, they may recommend blood tests, urine tests, or other laboratory tests to check for conditions such as an overactive thyroid, low blood sugar, diabetes, menopause, or infections[3][9].

Special sweat tests may be performed to identify the exact areas of excessive sweating and evaluate how severe your condition is. Two such tests are the iodine-starch test and sweat test, which use moisture-sensitive materials to show where sweating occurs[9].

Treatment options

Many effective treatments are available for hyperhidrosis. Treatment usually begins with addressing any underlying condition that may be causing the sweating. If no cause is found, treatment focuses on controlling the excessive sweating itself[9]. Even if your sweating improves with treatment, symptoms may return, requiring ongoing management[9].

Antiperspirants

For most cases of primary focal hyperhidrosis, topical aluminum chloride solution is the initial treatment[13]. Prescription-strength antiperspirants containing aluminum chloride should be applied to dry skin before going to bed, then washed off in the morning[9]. Once you start seeing results after using it daily for a few days, you can reduce application to once or twice a week to maintain the effect[9]. These products can cause skin and eye irritation, so talk with your healthcare provider about ways to reduce side effects[9].

Applying antiperspirant twice daily, in the morning and before bedtime, has been shown to be more effective in controlling excessive sweat than once-daily application[21]. Make sure skin is completely dry before applying the product to reduce the chance of skin irritation[21].

Prescription medications

For facial sweating, topical glycopyrrolate cream or wipes are considered first-line treatment[13]. These prescription medications work by blocking the chemical signals that activate sweat glands.

Oral anticholinergic medications may be prescribed as an adjunct treatment in severe cases when other treatments have failed[2][13]. These drugs work by interfering with nerve signals to the sweat glands, but they can have side effects such as dry mouth, blurred vision, and constipation.

Botulinum toxin injections

Injections of botulinum toxin (commonly known by the brand name Botox) are considered first- or second-line treatment for hyperhidrosis affecting the armpits, palms, soles, or face[2][13]. The treatment temporarily blocks the nerves that cause sweating. Results typically last up to six to seven months, and the treatment is often covered by insurance[14].

Iontophoresis

Iontophoresis is a treatment that uses a weak electric current passed through water or on a wet pad to temporarily shut down sweat glands[4][9]. It is particularly effective as first- or second-line treatment for excessive sweating of the palms and soles[13][14]. This treatment can be done in a doctor’s office or at home with proper equipment.

Other treatments

Local microwave therapy is a newer treatment option for underarm hyperhidrosis. This procedure uses microwave energy to destroy sweat glands[13].

For severe cases that do not respond to topical or medical therapies, surgical options may be considered. These include local surgery to remove sweat glands from the underarms or endoscopic thoracic sympathectomy, a procedure that disconnects the nerves responsible for producing excessive sweat[1][2][13]. Surgery should only be considered after other treatments have failed[13].

Self-care tips

In addition to medical treatments, several self-care strategies can help manage hyperhidrosis symptoms and improve your comfort in daily life.

Clothing choices

The fabrics and styles you wear can significantly affect your ability to manage hyperhidrosis. Choose loose-fitting clothes made from lightweight, breathable materials like cotton, bamboo, or moisture-wicking fabrics that help keep sweat away from your skin[17][20]. Wearing loose clothing enables perspiration to evaporate more easily[21].

Darker colors or busy patterns can conceal sweat marks more effectively than light or solid colors[20]. Avoid fabrics like silk or polyester, which can trap moisture and increase discomfort[20]. Layering with lightweight undershirts made of absorbent materials can provide an added barrier between sweat and your outer clothing[20].

Change your socks and shoes regularly to help prevent foot odor and skin problems[4][17]. Wear leather shoes and try to wear different shoes each day to allow them to dry completely[4]. Avoid enclosed boots or sports shoes that may cause your feet to sweat more[4].

Diet and hydration

What you eat and drink can influence your sweating. Stay well hydrated by drinking plenty of water early and often throughout the day[21]. Proper hydration helps regulate your body temperature and may reduce overall sweat production[20].

Avoid sweat-inducing foods and beverages such as spicy foods, caffeine, and alcohol, which can stimulate your nervous system and increase sweating[4][20][21]. Incorporate cooling, hydrating foods like cucumbers, watermelon, and leafy greens into your diet to support your body’s natural temperature regulation[20].

Daily hygiene practices

Keep fresh wipes or sweat pads on hand for on-the-go management[20]. Sweat pads or liners for your underarms can be discreetly tucked into clothing to absorb moisture throughout the day[20].

Use foot powders for sweaty feet and apply shoe spray to help control foot odor[8][17]. To knock out body odor, sprinkle baking soda on affected clothing and athletic gear after use[21].

Managing stress

Since anxiety can increase sweat production, controlling stress is important[21]. Practice relaxation techniques such as breathing deeply and focusing internally to help achieve calm[21].

If you exercise, avoid mid-day workouts when the sun is at its peak and the body is more inclined to sweat. Instead, take advantage of early morning or late evening hours when temperatures are cooler[21].

When to see a doctor

You should see your doctor if sweating disrupts your daily routine, causes emotional distress or social withdrawal, or if you suddenly begin to sweat more than usual[1]. If you experience night sweats for no apparent reason, this should also be discussed with your healthcare provider[1].

Seek immediate medical attention if you have heavy sweating accompanied by dizziness, pain in the chest, throat, jaw, arms, shoulders or throat, or cold skin and a rapid pulse, as these may be signs of a serious condition[1].

It’s important to see your doctor if things you can do yourself are not helping, if the excessive sweating has lasted for at least six months, if it stops you from getting on with daily activities, if it happens at least once a week, if it happens at night, if you have a family history of excessive sweating, or if you’re taking medicine for another condition[4].

Remember that hyperhidrosis is a treatable medical condition, and it is possible to manage symptoms through various treatment options[21]. A healthcare provider can help you find treatment that manages your symptoms and improves your quality of life[12].

Ongoing Clinical Trials on Hyperhidrosis

  • Study on the Effects of Tiotropium Bromide Gel for Patients with Severe Hand Sweating

    Not recruiting

    Investigated diseases:
    Spain

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