Ireland

Efficacy and Safety of Depemokimab for Early Intervention in Adults and Adolescents with Type 2 Asthma at Risk of Exacerbations

Recruiting

3 1 1
Investigated Drugs:
- Depemokimab
+3
Venetoclax added to fludarabine, cytarabine and gemtuzumab ozogamicin (drug combination) in children with relapsed acute myeloid leukemia

Recruiting

3 1 1 1
Investigated Diseases:
- Acute myeloid leukaemia
Investigated Drugs:
+8
Phase 1/2 Study of CR-001 Safety and Dose Finding in Adults with Locally Advanced or Metastatic Solid Tumors

Recruiting

2 1 1
Evaluation of NXT007 versus Emicizumab Prophylaxis in Patients with Hemophilia A

Recruiting

3 1 1 1
Investigated Diseases:
- Factor VIII deficiency
Investigated Drugs:
- Emicizumab
- Ro7589655
+5
Efficacy and safety of GB-0895 as adjunctive therapy in adults and adolescents with severe uncontrolled asthma (randomized, placebo‑controlled)

Recruiting

3 1

+1
Pumitamig Versus Durvalumab in Patients With Unresectable Stage III Non-Small Cell Lung Cancer Without Progression After Chemoradiation

Recruiting

3 1 1 1
Investigated Drugs:
- Durvalumab
+8

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ABO haemolytic disease of newborn Acquired ATTR amyloidosis Acute lymphocytic leukaemia Acute lymphocytic leukaemia recurrent Acute myeloid leukaemia Addison's disease Adenocarcinoma gastric Adenocarcinoma pancreas Adrenogenital syndrome Alpha-1 antitrypsin deficiency Alveolar proteinosis Amyotrophic lateral sclerosis Anaemia Anaemia of pregnancy Anti-glomerular basement membrane disease Antiphospholipid antibodies Arteriosclerosis Asthma Autonomic nervous system imbalance B-cell small lymphocytic lymphoma B-cell small lymphocytic lymphoma recurrent B-cell small lymphocytic lymphoma refractory Barth syndrome Biliary neoplasm Bladder cancer Bladder cancer stage II Bladder cancer stage III Bladder transitional cell carcinoma Breast cancer Breast cancer female Breast cancer male Breast cancer metastatic Breast cancer recurrent Breast cancer stage I Breast cancer stage II Breast cancer stage III Bronchiectasis Bronchopulmonary dysplasia Cachexia Carcinoid syndrome Cardiac amyloidosis Cardiac failure Cardiomyopathy Cardiovascular disorder CDKL5 deficiency disorder Central nervous system neoplasm Cerebrovascular accident Cervix carcinoma Cervix carcinoma recurrent Cholangiocarcinoma Chondrosarcoma Choroid melanoma Chronic graft versus host disease Chronic inflammatory demyelinating polyradiculoneuropathy Chronic left ventricular failure Chronic lymphocytic leukaemia Chronic lymphocytic leukaemia recurrent Chronic obstructive pulmonary disease Clear cell renal cell carcinoma Clostridium difficile infection Coeliac disease Colitis ulcerative Colon cancer Colorectal cancer Colorectal cancer metastatic Coronary artery disease COVID-19 Critical illness Crohn's disease Cystic fibrosis Cystic fibrosis respiratory infection suppression Decreased appetite Dementia Alzheimer's type Dermatitis atopic Diffuse large B-cell lymphoma Drug dependence Dry age-related macular degeneration Duchenne muscular dystrophy Elderly Embolic stroke Embolism venous Emphysema Endometrial adenocarcinoma Endometrial cancer Endometrial cancer recurrent Ependymoma Epidermolysis bullosa Factor IX deficiency Factor VIII deficiency Fallopian tube cancer Familial hypertriglyceridaemia Follicle centre lymphoma follicular grade I, II - III Follicular lymphoma Food allergy Fragile X syndrome Gastric cancer Gastrointestinal cancer metastatic Gastrooesophageal cancer Generalised tonic-clonic seizure Glioblastoma Glomerulonephritis membranous Haemolytic uraemic syndrome Haemophilia Haemophilia A with anti factor VIII Hepatobiliary cancer Hepatoblastoma Hepatocellular carcinoma HER2 positive breast cancer Hereditary angioedema Hereditary angioedema with C1 esterase inhibitor deficiency Hereditary haemochromatosis Hidradenitis HIV infection Hodgkin's disease Homocystinuria Hormone receptor positive breast cancer Hormone receptor positive HER2 negative breast cancer Hormone-dependent prostate cancer Hormone-refractory prostate cancer Hot flush Huntington's disease Hypergammaglobulinaemia benign monoclonal Hypertension Hypertrophic cardiomyopathy Hypoxic-ischaemic encephalopathy Idiopathic inflammatory myopathy Idiopathic pulmonary fibrosis Immune thrombocytopenia Indolent systemic mastocytosis Interstitial lung disease Iron deficiency anaemia Juvenile idiopathic arthritis K-ras gene mutation Left ventricular dysfunction Lung disorder Lung neoplasm malignant Lymphatic malformation Major depression Malignant glioma Malignant melanoma Malignant neoplasm of choroid Malignant peritoneal neoplasm Mantle cell lymphoma Marginal zone lymphoma Mechanical ventilation Metabolic dysfunction-associated steatohepatitis Metastatic renal cell carcinoma Monkeypox Monkeypox immunisation Myelodysplastic syndrome Myelodysplastic syndrome with excess blasts Myelofibrosis Myopia Myotonic dystrophy Neoplasm Neoplasm malignant Neovascular age-related macular degeneration Nephrogenic anaemia Nephropathy Neuroblastoma Non-alcoholic steatohepatitis Non-Hodgkin's lymphoma Non-small cell lung cancer Non-small cell lung cancer metastatic Non-small cell lung cancer recurrent Non-small cell lung cancer stage II Non-small cell lung cancer stage III Non-small cell lung cancer stage IIIA Non-small cell lung cancer stage IIIB Non-small cell lung cancer stage IV NTRK gene fusion overexpression Obesity Oesophageal adenocarcinoma Oesophageal adenocarcinoma stage II Oesophageal adenocarcinoma stage III Oesophageal carcinoma Oesophageal squamous cell carcinoma Oesophageal squamous cell carcinoma stage II Oesophageal squamous cell carcinoma stage III Open angle glaucoma Oropharyngeal cancer Osteochondrodysplasia Osteogenesis imperfecta Osteosarcoma Ovarian cancer Ovarian cancer metastatic Ovarian cancer recurrent Ovarian cancer stage III Ovarian epithelial cancer Ovarian epithelial cancer recurrent Overweight Pancreatic carcinoma Pancreatic carcinoma metastatic Paroxysmal nocturnal haemoglobinuria Partial seizures Patent ductus arteriosus PD-L1 positive cancer Phenylketonuria PIK3CA related overgrowth spectrum PIK3CA-activated mutation Plasma cell myeloma Plasma cell myeloma refractory Pneumonia Polycythaemia vera Polyneuropathy Porphyria non-acute Post-traumatic stress disorder Postoperative wound infection Premature baby Primary amyloidosis Primary myelofibrosis Procedural pain Prostate cancer Prostate cancer metastatic Psoriatic arthropathy Pulmonary arterial hypertension Pulmonary fibrosis Rectal cancer Relapsing multiple sclerosis Renal cancer metastatic Renal cell carcinoma Renal cell carcinoma stage IV Respiratory tract infection Retinal artery occlusion Rhabdomyosarcoma Richter's syndrome Secondary progressive multiple sclerosis Serous cystadenocarcinoma ovary Sickle cell disease Sjogren's syndrome Small cell lung cancer Small cell lung cancer extensive stage Small cell lung cancer recurrent Spinal muscular atrophy Squamous cell carcinoma Squamous cell carcinoma of head and neck Squamous cell carcinoma of lung Squamous cell carcinoma of skin Systemic lupus erythematosus Systemic mastocytosis Systemic scleroderma Testicular germ cell cancer Transitional cell cancer of the renal pelvis and ureter Transitional cell carcinoma Transitional cell carcinoma metastatic Transitional cell carcinoma urethra Triple negative breast cancer Type 2 diabetes mellitus Uveal melanoma Vascular malformation Von Willebrand's disease Waldenstrom's macroglobulinaemia

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