Clinical trials located in

Vila Nova de Gaia

Vila Nova de Gaia city is located in Portugal. Currently, 20 clinical trials are being conducted in this city.

Vila Nova de Gaia, located in Portugal, is renowned for its port wine cellars, where much of the world’s supply of port wine is aged and stored. The city sits on the south bank of the Douro River, directly opposite Porto, offering stunning views of its neighbor. Gaia’s origins trace back to Roman times, evident in its ancient ruins and historical sites. The Dom Luís I Bridge, a double-deck metal arch bridge that connects Gaia to Porto, is a notable landmark. Additionally, Gaia boasts beautiful beaches along its coastline, such as Praia da Aguda, and is home to the Monastery of Serra do Pilar, a UNESCO World Heritage Site.

  • CT-EU-00033046

    Testing a new combination therapy with acalabrutinib for a specific type of lymphoma

    This clinical trial is investigating a new combination therapy for diffuse large B-cell lymphoma, a type of lymphoma. The treatment combines Acalabrutinib, a targeted therapy drug, with R-CHOP, a chemotherapy mix consisting of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone, a standard chemotherapy regimen. The aim of the study is to evaluate the safety and effectiveness of this combination in improving patient outcomes. It focuses on patients who have not been previously treated for lymphoma. The study aims to find better treatment strategies for this particular type of lymphoma.

    • Prednisone
    • Vincristine
    • Doxorubicin
    • Acalabrutinib
    • Cyclophosphamide
    • Rituximab
  • Testing new immunotherapy combinations for non-small-cell lung cancer

    This study is testing a new treatment for non-small cell lung cancer that has not yet been treated with drugs. In the study, researchers will look at the effects of combining different immunotherapy drugs and their safety and effectiveness in treating cancer. Participants will receive various combinations of the drugs pembrolizumab, dostarlimab, belrestotug and GSK6097608. The study will last several years and will monitor the effects of different drug combinations and any potential side effects. The study aims to find new ways to treat lung cancer with fewer negative side effects.

    • Belrestotug
    • Dostarlimab
    • GSK6097608- new potential medication for solid tumors
    • Pembrolizumab
  • Study on new immunotherapy combinations for untreated advanced lung cancer

    This is a study of patients whose non-small cell lung cancer is at an advanced stage (cannot be cured by surgery or has spread to other parts of the body) and has not been previously treated. The study will test new combinations of immunotherapy (drugs that support the immune system in the fight against cancer) and compare them with a single immunotherapy drug. Scientists want to find out how well these combinations work and how safe they are. The study will also look at how the body processes these drugs. The drugs used in this study are called Belrestoug, GSK4428859A and EOS884448, but these names all refer to the same drug. Scientists will measure the effectiveness of the drugs by looking at how many patients have their cancer shrink and how long it takes for the cancer to start growing again or before the patient dies. They will also record any side effects that may occur during the study and for 90 days after the last treatment dose.

    • Belrestotug
    • Dostarlimab
    • GSK6097608- new potential medication for solid tumors
    • Pembrolizumab
  • Study of Tucatinib, Trastuzumab and Pertuzumab in the treatment of HER2+ metastatic breast cancer

    The study is aimed at patients with HER2-positive breast cancer whose disease has spread locally, i.e. close to where it started, and cannot be surgically removed, or has spread to other parts of the body. Treatment in this study includes a combination of drugs: tucatinib (also known as TUKYSA, ONT-380, ARRY-380), trastuzumab (Herceptin, Herceptin Hylecta), and pertuzumab (Perjeta). Some patients will receive a placebo instead of tucatinib.

    All patients will receive trastuzumab and pertuzumab, plus either tucatinib or placebo. Trastuzumab is administered intravenously (IV) or subcutaneously, and pertuzumab is administered intravenously. In some cases, trastuzumab and pertuzumab may be administered subcutaneously in combination.

    The aim of the study is to check whether tucatinib in combination with trastuzumab and pertuzumab works better than placebo. This will also check what side effects may occur while taking this drug combination. Side effects are any adverse effects a drug may have on the body in addition to treating the disease.

    The study includes patients who have already undergone 4-8 cycles of pre-treatment with trastuzumab, pertuzumab and taxane as first-line treatment for advanced breast cancer, and do not show disease progression after completion of this pre-therapy. Patients can have both positive and negative hormone receptor status.

    • Pertuzumab
    • Tucatinib
    • Trastuzumab
  • Research on plitidepsin effectiveness in treating COVID-19

    This research study aims to investigate the benefits and safety of a drug called plitidepsin for COVID-19 patients who have a weakened immune system and require hospital care. The study will administer the drug to some patients, while others will receive standard care, allowing researchers to assess whether plitidepsin can reduce death rates in this specific population. Throughout the study, close monitoring will be conducted to observe any changes, including side effects, serious incidents, or the necessity to discontinue the treatment.

    • Plitidepsin
  • Testing brepocitinib medicine’s effect on adult skin and muscle disease

    This study is going to check if a medicine called brepocitinib can help adults with a skin and muscle disease called dermatomyositis. The researchers are making sure that patient results are accurate by giving some people the actual medicine and others a placebo, which has no active substance. The researchers are comparing two different amounts of the medicine against the placebo one to see if the patients get better. It will be tracked by creating a score based on how severe 6 different signs of the disease are, and then tallying up these scores over a period of one year. Those who are part of this one year study can choose to extend their participation for another year, where everyone gets the medicine with active substance. The researchers determine if the patient has improved by looking for an increase in their score of 40 points or more. And also look at how well a person can do their daily tasks, and also score the severity of any skin issues they have at the start and end of the study to check for changes.

    • Brepocitinib
  • Pralsetinib vs regular care in treating advanced lung cancer

    This study is looking at how effective a medication called Pralsetinib is in treating a type of lung cancer called RET Fusion-Positive, Metastatic Non-Small Cell Lung Cancer. This cancer type is difficult to treat and usually spreads to other parts of the body. The medicine will be compared to the usual treatments given for this type of cancer. Doctors want to see if Pralsetinib can slow down or stop the cancer progression and how long that lasts. Any side effects experienced by patients will be carefully monitored to understand the medication’s safety.

    • Pralsetinib
    • Gemcitabine
    • Pemetrexed
    • Cisplatin
    • Carboplatin
    • Pembrolizumab
    • nab-Paclitaxel
    • Paclitaxel
  • Study on a new combination therapy for active ulcerative colitis

    This study aims to assess the effectiveness and safety of new combination therapy with JNJ-78934804 (Guselkumab/Golimumab) in comparison to guselkumab and golimumab administred alone for individuals with moderately to severely active ulcerative colitis. Participants who have shown inadequate response, loss of response, or intolerance to approved advanced therapies will be included. The trial includes various treatment groups: placebo, Guselkumab, Golimumab, and different doses of JNJ-78934804. All participants meeting inadequate response criteria will be escalated to an active treatment. The study will last for 48 weeks and the progress will be tracked over this period. The primary focus is to evaluate the efficacy and safety of the different doses of new therapy in managing ulcerative colitis over the course of the study.

    • JNJ-78934804/guselkumab + golimumab
    • Golimumab
    • Guselkumab
  • Testing mavacamten for heart muscle disease

    This study aims to assess a drug called Mavacamten for a heart condition called Non-Obstructive Hypertrophic Cardiomyopathy. Patients will be randomly given either the actual drug or a placebo without anyone knowing which one they’ve received. The study will measure how safe and effective the drug is for patients with symptoms of this heart condition. The success of the drug will be determined by preventing heart-related issues such as heart attacks, strokes, heart failures, irregular heartbeats, and the need for a heart-rhythm controlling device.

    • Mavacamten
  • Comparison of different treatments for follicular lymphoma

    This study involves comparing two treatments for a condition known as follicular or marginal zone lymphoma, both of which are types of cancer affecting lymph cells. The first treatment combines zanubrutinib with an antibody called Anti-CD20, while the second treatment involves lenalidomide and rituximab. These treatments are intended for patients who have not responded or have stopped responding to conventional treatment. One of the primary objectives of the study is to determine which treatment is more effective in preventing the cancer from progressing, referred to as progression-free survival. Additionally, the study aims to assess the impact of these treatments on the patients’ quality of life, evaluating various aspects through questionnaires related to physical and emotional well-being, symptoms, and the ability to perform normal activities.

    • Zanubrutinib
    • Obinutuzumab
    • Lenalidomide
    • Rituximab
  • Study on dazostinag & pembrolizumab for advanced solid tumors

    The purpose of this study is to test a new drug called dazostinag. A study is being conducted to see whether this drug is helpful in adults with advanced forms of solid cancer. Some people are given dazostinag alone, while others are given it with another medicine called pembrolizumab. Scientists’ focus here is on finding out whether these drugs cause any side effects, and finding out what the maximum dose is that people can take without serious side effects. The study consists of two parts, including a dose escalation phase and a dose escalation phase. In the first part, the dose of dazostinag will be gradually increased, given alone or in combination with pembrolizumab. In the second part, Dazostinag will be tested with pembrolizumab and other anticancer drugs. This section will focus on patients with specific cancers that are difficult to remove or have spread to other parts of the body.

    • Dazostinag
    • Platinum
    • Pembrolizumab
    • 5-Fluorouracil
  • Assessing olpasiran treatment for heart disease and elevated cholesterol

    Tests named ‘OCEAN(a)’ are being conducted, focusing on a medication called ‘olpasiran’. Put simply, the potential of this medication in preventing serious heart episodes in individuals with Atherosclerotic Cardiovascular Disease and an elevated level of a fat protein, Lipoprotein(a), is under examination. The effect of a harmless, dummy pill (placebo) is compared to that of the actual medication, olpasiran, in individuals with these conditions. The primary goal is to determine whether olpasiran can reduce the risk of death due to heart disease, occurrence of heart attacks, or the necessity for sudden surgery to clear blocked heart vessels.

    • Olpasiran
  • Testing the efficacy of teclistamab vs other drugs for relapsed or refractory multiple myeloma treatment

    The study is evaluating a treatment for a blood cancer known as multiple myeloma. Two different treatments are being compared to assess their effectiveness in both slowing down the disease and minimizing side effects. The first treatment involves a single medicine called teclistamab, while the second offers a choice between two combinations of multiple medicines (either PVd – pomalidomide, bortezomib, dexamethasone or Kd – carfilzomib, dexamethasone). Both treatments have been previously administered to individuals with similar conditions. Individuals who have undergone prior treatment, including the use of an anti-CD38 monoclonal antibody and lenalidomide, but experienced a recurrence or lack of resolution of the disease, are eligible to participate in this study. The objective is to determine the duration it takes for the disease to progress under different treatments. Additionally, the study will monitor changes in health and potential medication-related issues through regular check-ups.

    • Carfilzomib
    • Pomalidomide
    • Teclistamab
    • Dexamethasone
    • Bortezomib
  • Testing the safety and effectiveness of a new drug in the treatment of pulmonary fibrosis

    This study is testing a new drug called BMS-986278 for a lung disease called progressive pulmonary fibrosis. This condition causes the lungs to become increasingly scarred over time, making breathing difficult. Randomly assigned participants will receive either the real drug or a fake drug (placebo) that doesn’t work. No one will know who gets what, not even doctors. The goal is to see if this new drug helps slow the progression of the disease, prevent patients from having to be hospitalized and/or increase their chances of survival. These outcomes will be measured by tracking breathing tests, any sudden, serious worsening of the disease, any hospital stays related to lung disease, and any deaths from any cause.

    • BMS-986278- new potential medication for idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF)
  • Studying effects of tozorakimab on Chronic Obstructive Pulmonary Disease (COPD)

    This clinical study evaluates the efficacy and safety of Tozorakimab in treating adults with Chronic Obstructive Pulmonary Disease (COPD) who have a history of frequent exacerbations. Participants, who must have experienced at least two moderate or one severe exacerbation in the past year, will receive tozorakimab through subcutaneous injections. The study aims to reduce the rate of COPD exacerbations over a one-year period. Participants will continue their usual inhaled lung therapies alongside the trial treatments.

    • Tozorakimab
  • Study of Early Breast Cancer Using Camizestrant or Hormone Therapy for Patients at Risk of Recurrence After At Least 2 Years of Standard Therapy

    The clinical trial focuses on patients with early-stage ER+/HER2- breast cancer, meaning the cancer is hormone-receptor-positive (ER+) and does not have an excess of the HER2 protein (HER2-). Participants must have an intermediate or high risk of disease recurrence and must have completed definitive locoregional therapy (such as surgery or radiotherapy) and at least 2 years but not more than 5 years of standard hormone therapy.

    The aim of the study is to assess the efficacy and safety of the drug Camizestrant (AZD9833) compared to standard hormone therapy, which may include aromatase inhibitors (e.g., letrozole, anastrozole, exemestane) or tamoxifen.

    Key measures will include the time to the recurrence of invasive breast cancer, invasive disease-free survival, distant relapse-free survival, overall survival, and the safety of the therapies used.

    Both women and men over 18 years old who meet specific criteria can participate in the study. Therapeutic effects and potential side effects will be monitored during the treatment. Patients will be observed for 10 years from the time of randomization into one of the study groups.

    • camizestrant
    • Anastrozole
    • Letrozole
    • Exemestane
    • tamoxifen
  • Studying tozorakimab for long-term safety in patients with chronic obstructive pulmonary disease

    The research study focuses on Tozorakimab’s long-term safety and efficacy in adults over 40 with frequent COPD flare-ups. It aims to evaluate the time until the first severe flare-up post-treatment, comparing it with the effects of current COPD treatments. The study also assesses Tozorakimab’s additional benefits alongside standard care and monitors participants’ blood for drug levels and physiological reactions. This research is key in developing improved management strategies for COPD.

    • Tozorakimab
  • Drug study – AZD9833 in advanced HR+/HER2- breast cancer with ESR1 mutation

    The study focuses on advanced breast cancer, specifically hormone receptor-positive (HR-positive) and human epidermal growth factor receptor 2-negative (HER2-negative) cases. These patients show an ESR1 gene mutation that might cause current treatments to stop working well. The body’s inability to control cell growth leads to tumors in the breast, and when these tumors spread to other parts of the body, it becomes advanced cancer.

    AZD9833, an unapproved trial drug, will be compared with two existing treatments: palbociclib, abemaciclib, and ribociclib (which block tumor growth), and letrozole and anastrozole (aromatase inhibitors, AI), to see if it works better when combined with palbociclib, abemaciclib, or ribociclib in patients with the ESR1 mutation.

    Participants will either continue their current combination of AI and CDK4/6 inhibitor or switch to AZD9833 and a CDK4/6 inhibitor. The goal is to see which combination is better at extending the time before the cancer gets worse and to learn more about AZD9833’s safety.

    Participants in this trial will have been receiving combinations of an AI and a CDK4/6 inhibitor beforehand. During the trial, they will remain on the same CDK4/6 inhibitor.

    Participants will be split into two groups: Group A will receive AZD9833, a CDK4/6 inhibitor, and a placebo. Group B will receive an AI, a CDK4/6 inhibitor, and a placebo.

    The treatments will be taken daily in 28-day cycles as follows: either AZD9833 or an AI plus the placebo. If taking abemaciclib: twice daily for 28 days. If taking palbociclib or ribociclib: once daily for 21 days, followed by a 7-day break. This 28-day cycle will repeat for the duration of participation in the trial.

    • Camizestrant
    • Luteinizing hormone-releasing hormone (LHRH) agonist
    • Abemaciclib
    • Palbociclib
    • Ribociclib
    • Anastrozole
    • Letrozole
  • Evaluation of the effectiveness of combined therapy in the treatment of bladder cancer with muscle invasion

    This clinical study, known as the VOLGA trial, is for bladder cancer patients who cannot or refuse to take Cisplatin. Two new therapy combinations are being tested. The first combines Durvalumab, Tremelimumab, and Enfortumab Vedotin. The second partners Durvalumab with Enfortumab Vedotin only. Patients receive these drugs both before and after having bladder surgery. This study wants to involve about 830 patients and will assign them blindly to the therapy combinations. Patients will receive the blend for three cycles, with more Durvalumab treatments after surgery. We want to track if the cancer is eradicated after surgery, when the cancer appears again, the survival rate, unwanted effects, and the patients’ well-being. Taking part in this study might require commitment for approximately 3-5 years, with follow-ups to monitor the patient’s progress.

    • Enfortumab vedotin
    • Tremelimumab
    • Durvalumab
  • Study of new drugs in acute lymphoblastic leukemia

    This clinical trial focuses on improving treatment strategies for acute lymphoblastic leukemia (ALL) in a diverse age group, from infants to young adults up to 45 years old. The study combines standard treatments with new drugs, for example, Inotuzumab Ozogamicin and Blinatumomab. The trial aims to tailor treatment to individual patient needs and reduce toxicity while maintaining treatment quality. By carefully monitoring event- and disease-free survival rates, as well as minimal residual disease responses, the trial aims to improve the standard of care for ALL and improve both survival outcomes and patient quality of life.

    • Inotuzumab Ozogamicin
    • 6-tioguanine
    • Blinatumomab
    • Imatinib
    • Dexamethasone
    • Vincristine
    • Doxorubicin

See more clinical trials in other cities in Portugal:

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