Innovative studies focusing on autoimmune conditions including trials evaluating new treatments for psoriatic and rheumatoid arthritis. Research includes assessment of maintenance therapies and novel drug combinations.

Psoriatic Arthritis Treatment
Rheumatoid Arthritis Management
Sjögren's Disease Therapies

Particular emphasis on evaluating long-term treatment efficacy and bone erosion prevention.

02 Oncology Studies

Comprehensive research in hematologic malignancies and solid tumors, with significant focus on multiple myeloma and breast cancer treatment innovations.

Multiple Myeloma Therapies
Triple Negative Breast Cancer
Pancreatic Adenocarcinoma

Advanced treatment protocols combining immunotherapy with traditional approaches.

03 Infectious Disease Research

Cutting-edge studies in HIV treatment and viral infections, exploring new therapeutic approaches and treatment optimization strategies.

HIV-1 Treatment Innovations
Viral Lung Infections
Immunotherapy Applications

Focus on developing long-acting treatments and improving patient outcomes.

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Clinical trials in Orléans – page 6

146 trials in Orléans

Efficacy of dapagliflozin in adult patients with septic shock and microcirculatory dysfunction

Efficacy of dapagliflozin in adult patients with septic shock and microcirculatory dysfunction

Study of nemtabrutinib combined with venetoclax and obinutuzumab in untreated CLL/SLL patients with TP53 alterations

Study of nemtabrutinib combined with venetoclax and obinutuzumab in untreated CLL/SLL patients with TP53 alterations

Pyelonephritis

Fosfomycin trometamol versus drug combination for treating acute E. coli pyelonephritis in women aged 75 years and older

Bacterial sepsis

Individualized beta‑lactam dosing with piperacillin (drug combination) for ICU patients with sepsis caused by gram‑negative bacteria

Systemic scleroderma

Safety and efficacy of obinutuzumab in patients with active diffuse systemic sclerosis: a randomized, double-blind, placebo-controlled trial

Pain

Methoxyflurane for Rapid Relief of Non‑Traumatic Pain in Adult Emergency Department Patients: A Randomized Controlled Trial

Pneumonia+1

Early Use of Dexamethasone versus Sodium Chloride Placebo in Patients with Severe Influenza-Induced Acute Hypoxemic Respiratory Failure (Phase III Randomized Trial)

T-cell type acute leukaemia

Evaluating venetoclax with drug combination in relapsed/refractory T‑cell acute lymphoblastic leukemia patients

Systemic scleroderma

Rituximab versus placebo for maintenance therapy in adults with stabilized systemic sclerosis‑associated interstitial lung disease

Hormone receptor positive HER2 negative breast cancer

Study evaluating the omission of exemestane, letrozole, anastrozole, and tamoxifen in postmenopausal women with low-risk early breast cancer.

Osteoarthritis

A study to evaluate the effect of topical clobetasol propionate versus a placebo for the treatment of inflammatory hand osteoarthritis in adults.

Plasma cell myeloma

A study of belantamab mafodotin and mezigdomide in patients with relapsed multiple myeloma who have previously received CAR-T cell therapy or bispecific antibodies

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