Clinical trials in Leiden – page 74

1 938 clinical trials in Leiden, The Netherlands across 4 research sites. Every trial is listed in the EU Clinical Trials Register and updated daily.

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1 938

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1 938 trials in Leiden

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Craniopharyngioma

Not yet recruiting

A study of tovorafenib for children and young adults with newly diagnosed or recurrent craniopharyngioma

InvestigationalNo placebo

A study of tovorafenib for children and young adults with newly diagnosed or recurrent craniopharyngioma

InvestigationalNo placebo

The Netherlands

Participants:0–17 years · 18–64 years
Substances:Tovorafenib
Sponsor:Prinses Maxima Centrum voor Kinderoncologie B.V.

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Lung neoplasm malignant

Not yet recruiting

Study of osimertinib and febuxostat to improve drug delivery in patients with EGFR-mutated non-small cell lung cancer without brain metastases

Registered drugNo placebo

Study of osimertinib and febuxostat to improve drug delivery in patients with EGFR-mutated non-small cell lung cancer without brain metastases

Registered drugNo placebo

The Netherlands

Participants:18–64 years · 65+ years
Substances:Febuxostat
Sponsor:University Hospital Maastricht

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Malignant melanoma stage IV+1

Not yet recruiting

A study of ipilimumab and nivolumab to observe immune system changes in patients with unresectable stage III or IV melanoma

Registered drugNo placebo

A study of ipilimumab and nivolumab to observe immune system changes in patients with unresectable stage III or IV melanoma

Registered drugNo placebo

The Netherlands

Participants:18–64 years · 65+ years
Substances:Ipilimumab
Sponsor:Amsterdam UMC Stichting

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Cholelithiasis+2

Not yet recruiting

A study to evaluate if atorvastatin prevents gallstones in patients undergoing bariatric surgery

Registered drugNo placebo

A study to evaluate if atorvastatin prevents gallstones in patients undergoing bariatric surgery

Registered drugNo placebo

The Netherlands

Participants:18–64 years
Substances:Atorvastatin
Sponsor:Spaarne Gasthuis Stichting

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Post-traumatic stress disorder

Not yet recruiting

A study to evaluate if hydrocortisone helps reduce symptoms of post-traumatic stress disorder in patients after exposure to a traumatic event.

Registered drug

A study to evaluate if hydrocortisone helps reduce symptoms of post-traumatic stress disorder in patients after exposure to a traumatic event.

Registered drug

The Netherlands

Participants:18–64 years · Healthy volunteers
Substances:Hydrocortisone
Sponsor:Amsterdam UMC Stichting

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Stomatitis

Not yet recruiting

Comparison of esketamine hydrochloride mouthwash and intravenous esketamine to reduce pain from oral mucositis in patients undergoing hematopoietic stem cell transplantation

Registered drugNo placebo

Comparison of esketamine hydrochloride mouthwash and intravenous esketamine to reduce pain from oral mucositis in patients undergoing hematopoietic stem cell transplantation

Registered drugNo placebo

The Netherlands

Participants:18–64 years · 65+ years
Substances:Esketamine
Sponsor:Amsterdam UMC Stichting

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Pulmonary fibrosis

Not yet recruiting

A study to evaluate the effectiveness and safety of admilparant in patients with progressive pulmonary fibrosis

Investigational

A study to evaluate the effectiveness and safety of admilparant in patients with progressive pulmonary fibrosis

Investigational

The Netherlands

Participants:18–64 years · 65+ years
Substances:Admilparant
Sponsor:Bristol-Myers Squibb Services Unlimited Company

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Endometrial cancer+7

Not yet recruiting

A study to evaluate the safety of SGN-ALPV in patients with advanced solid tumors

InvestigationalNo placebo

A study to evaluate the safety of SGN-ALPV in patients with advanced solid tumors

InvestigationalNo placebo

The Netherlands

Participants:18–64 years · 65+ years
Substances:SGN-ALPV
Sponsor:Seagen Inc.

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Glioblastoma

Not yet recruiting

Phase 3 Randomized Study of Niraparib Tosilate Monohydrate vs. Temozolomide in Newly Diagnosed MGMT Unmethylated Glioblastoma

Registered drugNo placebo

Phase 3 Randomized Study of Niraparib Tosilate Monohydrate vs. Temozolomide in Newly Diagnosed MGMT Unmethylated Glioblastoma

Registered drugNo placebo

The Netherlands

Participants:18–64 years · 65+ years
Substances:Temozolomide
Sponsor:Neurotrials LLC

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Plasma cell myeloma refractory

Not yet recruiting

A Study of Linvoseltamab Alone and Linvoseltamab with Carfilzomib Compared to Standard Treatment in Adults with Relapsed or Refractory Multiple Myeloma

Registered drugNo placebo

A Study of Linvoseltamab Alone and Linvoseltamab with Carfilzomib Compared to Standard Treatment in Adults with Relapsed or Refractory Multiple Myeloma

Registered drugNo placebo

The Netherlands

Participants:18–64 years · 65+ years
Substances:Aciclovir
Sponsor:Regeneron Pharmaceuticals Inc.

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Cerebral palsy

Not yet recruiting

Comparison of intrathecal baclofen pump and selective dorsal rhizotomy for children with cerebral palsy who cannot walk

Registered drugNo placebo

Comparison of intrathecal baclofen pump and selective dorsal rhizotomy for children with cerebral palsy who cannot walk

Registered drugNo placebo

The Netherlands

Participants:0–17 years
Substances:Baclofen
Sponsor:UZ Leuven

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Acute lymphocytic leukaemia+6

Not yet recruiting

A Study Testing the Safety of CD19-Targeted CAR T-Cell Therapy in Children and Young Adults with Relapsed or Refractory B-Cell Cancers

InvestigationalNo placebo

A Study Testing the Safety of CD19-Targeted CAR T-Cell Therapy in Children and Young Adults with Relapsed or Refractory B-Cell Cancers

InvestigationalNo placebo

The Netherlands

Participants:0–17 years · 18–64 years
Substances:MB-HUCART19.1
Sponsor:Prinses Maxima Centrum voor Kinderoncologie B.V.

Contact Research Centre

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Clinical research in Leiden

What the registry says about research in the country

01 Infectious Diseases Research

Innovative studies focusing on viral infections including trials evaluating vaccines against yellow fever, influenza, and mpox. Research includes assessment of antibody responses and vaccine effectiveness in different populations.

Influenza vaccine efficacy in elderly
Yellow fever prophylaxis
Mpox booster vaccination

Particular emphasis on preventive strategies and immune response evaluation.

02 Neurological Studies

Comprehensive research targeting neurological conditions, including investigations into Parkinson's disease treatments and neural response patterns. Studies examine innovative therapeutic approaches.

Parkinson's Disease treatments
CNS response analysis
Cerebral Amyloid Angiopathy

Focus on developing targeted therapies and understanding brain mechanisms.

03 Cancer and Chronic Conditions

Advanced research in oncology and chronic diseases, including studies on gastric cancer imaging and T-cell lymphoma treatments. Investigations into kidney disease management.

Advanced solid tumors
Gastric cancer diagnosis
Chronic kidney disease

Emphasis on innovative diagnostic techniques and treatment approaches.

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