endometriosis is a condition in which tissue similar to the lining of the uterus grows outside the uterus, often causing pain and fertility problems. In this study an experimental imaging substance called [18F]AlF-FAPI-74 is injected into a vein and a special whole‑body scan called PET/CT is performed. This scan creates detailed pictures that show areas where the abnormal tissue is active, helping doctors see the disease without surgery.
The purpose of the study is to find out whether this new scan can accurately identify deep or superficial endometriosis compared with the current standard method, which is a small‑incision surgical examination known as laparoscopy. Participants will have the injection and scan, and later will undergo the routine surgical procedure so the two sets of findings can be compared. Additional routine imaging tests such as MRI or ultrasound may also be done if they are already part of the patient’s care.
After the initial scan, participants may have a second scan if they start hormone‑blocking medication (often called a GnRH‑agonist or GnRH‑antagonist) to see how the disease changes. Throughout the study, safety is monitored and any side effects are recorded. The overall aim is to determine if this non‑invasive imaging approach can help doctors diagnose and manage endometriosis more effectively.
Belgium 
