Digestive System Diseases

The department is investigating new therapies for primary biliary cholangitis‑related itching and assessing peri‑operative treatment options for colon cancer with mismatch repair deficiency.

  • Primary biliary cholangitis – cholestatic pruritus
  • Resectable colon cancer – dMMR/MSI‑H

Hopital Huriez conducts eight trials with a team of 25 investigators, emphasizing patient‑focused outcomes in digestive health.

Hemic and Lymphatic Diseases

Studies target advanced blood‑cell malignancies, evaluating novel conditioning regimens for transplant and a bispecific antibody in Mantle Cell Lymphoma.

  • Mantle Cell Lymphoma
  • Acute myeloid leukemia

The research aims to improve survival and reduce treatment‑related toxicity for patients with hematologic cancers.

Immune System Diseases

Clinical work focuses on autoimmune conditions, testing long‑term safety of a novel agent in Sjögren’s syndrome and measuring disease activity reduction in systemic lupus erythematosus.

  • Sjögren’s syndrome
  • Systemic lupus erythematosus

These trials seek to provide better symptom control and disease‑modifying options for patients with immune‑mediated disorders.

Neoplasms

The site evaluates innovative cancer therapies, including a single‑agent bispecific antibody for relapsed Mantle Cell Lymphoma and a checkpoint inhibitor used before surgery in colon cancer.

  • Mantle Cell Lymphoma
  • Colon cancer – resectable disease

By comparing progression‑free survival and overall outcomes, the research supports advances in solid‑tumor and hematologic oncology.

Virus Diseases

A trial investigates the efficacy of an AXL‑inhibitor in hospitalised patients with moderate SARS‑CoV‑2 infection, aiming to reduce disease severity.

  • COVID‑19

The study contributes to the development of targeted treatments for emerging viral threats.

Environment and Public Health

Through its infectious‑disease program, the centre supports broader public health goals by generating evidence on safe, effective therapies that can be deployed in community settings.

  • Infectious disease clinical research
  • Trial infrastructure for population health

The work at Hopital Huriez helps inform health policies and preparedness strategies across the region.