A study of daraxonrasib (RMC-6236) compared to observation in patients with resected pancreatic cancer following chemotherapy

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What is this study about?

This study focuses on individuals with Pancreatic Ductal Adenocarcinoma, which is a type of cancer that begins in the ducts of the pancreas. The research specifically involves patients who have undergone surgical removal of the tumor, known as resected cancer, and have already finished neoadjuvant or adjuvant chemotherapy. Neoadjuvant refers to treatment given before surgery to shrink a tumor, while adjuvant refers to treatment given after surgery to help remove any remaining cancer cells.

The purpose of this study is to compare the effectiveness of a new drug called daraxonrasib, also known by its code name RMC-6236, against the current standard of care, which involves close observation by medical professionals. Daraxonrasib is an oral medication taken in the form of a tablet.

During the study, participants are assigned to one of two groups through a process called randomization. One group will receive the experimental drug, while the other group will receive the standard observation. The course of the study involves monitoring patients over time to see how long they remain free from the disease and to track overall survival.

Who Can Join the Study?

  • You must be at least 18 years old and agree to participate in the study by signing a consent form.
  • You must have an ECOG performance status of 0 or 1, which means you are able to carry out most daily activities and are physically active.
  • You must have a confirmed diagnosis of pancreatic ductal adenocarcinoma (a type of pancreatic cancer) that has been surgically removed.
  • The surgery must have been performed with curative intent (meaning the goal was to remove all cancer) and there must be no signs that the cancer has returned or spread to other parts of the body.
  • You must have received perioperative chemotherapy, which is medicine used to treat cancer either before or after surgery.
  • Your most recent round of cancer treatment must have ended within the last 12 weeks.
  • You must have adequate organ function, meaning your bone marrow (the part of your body that makes blood cells), liver, kidneys, and coagulation (your blood’s ability to clot) are all working well.
  • You must have a documented RAS mutation status, which is a test result showing if there are specific changes in the genes that control how cells grow.
  • You must be able to swallow and take oral medications (pills or liquids taken by mouth).

Who Cannot Join the Study?

  • You have previously used a treatment that specifically targets RAS, which is a type of protein in the body that helps cells grow.
  • You have any health conditions that might prevent your body from being able to take or absorb the study medication properly.
  • You have had any major surgery within the 28 days before being assigned to a treatment group.
  • You are unable or do not wish to follow the study protocol, which is the set of rules and specific steps required for the clinical trial, including attending all scheduled visits and procedures.

Where you can join this trial?

Verified and Recommended Sites

No sites found in this category

Verified Sites

Other Sites

Site Name City Country Status
Krankenhaus Nordwest GmbH Frankfurt Germany
Istituto Oncologico Veneto Padua Italy
Istituto Europeo Di Oncologia S.r.l. Milan Italy
Centro Ricerche Cliniche Di Verona S.r.l. Verona Italy
Hospital Edouard Herriot Lyon France
Hospital Universitario 12 De Octubre Madrid Spain
Universitaetsklinikum Schleswig-Holstein AöR Kiel Germany
Virgen del Rocío University Hospital Sevilla Spain
Hospital Clinic De Barcelona Barcelona Spain
Institut fuer Klinische Transfusionsmedizin und Immungenetik Ulm gGmbH Ulm Germany
Fondazione I.R.C.C.S. Istituto Neurologico Besta Milan Italy
Hospital Paul Brousse Villejuif France
Centre De Lutte Contre Le Cancer Eugene Marquis Rennes France
Azienda Ospedaliero Universitaria Pisana Pisa Italy
Ekysgryepjkmfsvm Bfknur Bfrajwzzphb Berlin Germany
Kxirmhmm dok Uyaqmgbbvsay Myxxsyiy Aid Munich Germany
Hqtyvkxl Vimy dczzvdlc Barcelona Spain
Iooxkaac Pyqscylxpjvptzd Cfispe Cpkjsj Marseille France

Want to learn more about this study or check if you can participate? Contact us.

Trial status

Country Status Recruitment Start
France France
Recruiting
27.05.2026
Germany Germany
Not yet recruiting
27.05.2026
Italy Italy
Recruiting
27.05.2026
Spain Spain
Not yet recruiting
27.05.2026

Trial locations

Daraxonrasib is an experimental oral medication being tested to see if it can help prevent the cancer from returning in patients who have had surgery to remove pancreatic cancer after completing chemotherapy.

Pancreatic ductal adenocarcinoma – This is a type of cancer that starts in the narrow tubes, called ducts, which carry digestive juices through the pancreas. The disease typically begins in the cells lining these ducts and can grow uncontrollably. As it progresses, the abnormal cells may form a mass and spread to nearby tissues or other parts of the body. In cases where the tumor has been surgically removed, the disease may still reappear in the same location or elsewhere.

Trial ID:
2025-523495-23-00
Protocol code:
RMC-6236-304
NCT ID:
NCT07252232
Trial Phase:
Therapeutic confirmatory (Phase III)

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