This study looks at dyspepsia, which is a condition that causes discomfort or pain in the upper part of the stomach, often described as indigestion. People with dyspepsia may experience symptoms such as bloating, feeling full quickly, nausea, or a burning sensation in the stomach area. The treatment being used in this study is esomeprazole, a medication that reduces the amount of acid produced in the stomach. This type of medication is commonly used to help relieve symptoms related to stomach acid. In addition to esomeprazole, the study also includes a product called Rennie, which contains calcium carbonate and magnesium carbonate and is used as a rescue medication for quick relief of symptoms when needed.

The purpose of this study is to compare two different lengths of treatment with esomeprazole to see if a shorter treatment period works as well as a longer one in reducing dyspepsia symptoms. Some people in the study will take esomeprazole for seven days, while others will take it for four weeks. The study will measure changes in symptoms using a scoring system called the Glasgow Dyspepsia Severity Score, which tracks how severe the symptoms are over time. The study aims to determine whether the shorter treatment is not worse than the longer treatment, meaning it provides similar relief.

During the study, participants will take esomeprazole by mouth according to their assigned treatment schedule. They will record their symptoms daily so that researchers can track any changes. The maximum daily dose of esomeprazole will be 40 milligrams, and participants may use Rennie as needed for additional symptom relief. The study will last for several weeks, during which time participants will continue to monitor their symptoms. If symptoms do not improve or worsen, participants may be referred for an upper gastrointestinal endoscopy, which is a procedure that allows doctors to look inside the stomach and upper digestive tract using a thin tube with a camera.