Comparing low-dose and standard-dose argatroban or enoxaparin to prevent blood clots in patients with heart or lung failure receiving extracorporeal membrane oxygenation.

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What is this study about?

This study is intended to compare different ways of preventing blood clots in patients receiving Extracorporeal Membrane Oxygenation, which is a method used to support the function of the heart and lungs by circulating blood through an external machine. The conditions being studied are Heart Failure and Lung Failure. Participants will receive treatment with either argatroban or enoxaparin through an intravenous infusion, which is a way of delivering medication directly into a vein. Argatroban and enoxaparin are types of anticoagulants, which are substances used to prevent blood from clotting too much.

The study examines whether using a low dose or a standard dose of these medications is safer and more effective. The amount of medication given will be monitored using specific laboratory tests, such as the anti-IIa assay or the anti-Xa assay, which are methods used to measure how well the blood is being thinned. These tests help ensure that the blood does not become too thick, causing clots, or too thin, which could lead to bleeding.

Who Can Join the Study?

  • You must be using ECMO, which is a machine that acts as an artificial heart and lung to help your body pump blood and take in oxygen.
  • You must be receiving anticoagulation treatment, which means you are taking medicine to prevent blood clots from forming.
  • The specific medicines being used for your blood thinning must be argatroban or enoxaparin.
  • You must be 18 years of age or older.
  • You or your legal representative must provide informed consent, which means you have been given all the necessary information about the study and have formally agreed to participate.

Who Cannot Join the Study?

  • You are currently enrolled in the lung transplant program, which is a specialized medical program for people who need a new lung.
  • You have a known hypersensitivity, which means your body has an abnormally strong or unusual reaction, to any part of the study medications.
  • You have had an allergic reaction, which is an immune system response that can cause symptoms like itching, swelling, or trouble breathing, to the active ingredients in the study medications.
  • You are pregnant or currently breastfeeding.

Where you can join this trial?

Verified and Recommended Sites

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Verified Sites

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Other Sites

Site Name City Country Status
University Hospital Ostrava Ostrava Czechia
Fhbzmcxo nqomoebln Mkvps a Hemdyrl Prague Czechia

Want to learn more about this study or check if you can participate? Contact us.

Trial status

Country Status Recruitment Start
Czechia Czechia
Not yet recruiting
02.03.2026

Trial locations

Argatroban is a medication used to prevent blood clots from forming in the bloodstream. In this study, it is being tested to see how well it works to keep blood flowing smoothly while a patient is receiving specialized breathing and heart support.

Enoxaparin is a type of medicine that thins the blood to help prevent dangerous blood clots. This study investigates its use in helping patients stay safe from clotting while they are on life support machines.

Heart failure – This condition occurs when the heart muscle cannot pump blood as effectively as it should to meet the body’s needs. It often develops gradually as the heart becomes weakened or stiff over time. As the condition progresses, the heart may struggle to circulate enough oxygen-rich blood to vital organs. This can lead to a buildup of fluid in the lungs and other parts of the body. The severity can increase as the heart works harder to compensate for its reduced pumping capacity.

Lung failure – This condition happens when the lungs can no longer perform their essential function of transferring oxygen into the blood and removing carbon dioxide. It can result from various underlying issues that damage the lung tissue or the air sacs. As the disease advances, the levels of oxygen in the bloodstream may drop significantly. This progression often leads to increased difficulty in breathing and impaired gas exchange. Over time, the respiratory system becomes increasingly unable to support the body’s metabolic requirements.

Trial ID:
2025-524553-13-00
Trial Phase:
Therapeutic exploratory (Phase II)

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