Multiple Sclerosis
Clinical research in relapsing-remitting multiple sclerosis and primary progressive multiple sclerosis with interest in ocrelizumab therapeutic monitoring and the relationship between serum drug concentrations and clinical markers.
- Ocrelizumab serum concentration monitoring
- Personalized pharmacotherapy
- Clinical and paraclinical indicators
The research activity in this area centers on treatment individualization in neuroimmunology and the optimization of disease-modifying therapy.
Heart Failure
Studies focus on chronic heart failure with reduced ejection fraction and related lung and heart failure, with emphasis on drug-level assessment and its association with functional and clinical outcomes.
- Therapeutic drug monitoring
- Heart failure pharmacotherapy
- Serum concentration–response relationships
The main therapeutic interest lies in refining medication use in cardiology through measurement of circulating drug levels and metabolite patterns.
Orthopaedic Pain Management
Clinical work in proximal femur fracture care includes evaluation of intrathecal morphine for postoperative analgesia in patients undergoing surgical treatment.
- Intrathecal opioid administration
- Postoperative analgesia
- Orthopaedic surgery pain control
This area reflects interest in improving perioperative pain management for major fracture repair.
Extracorporeal Support and Anticoagulation
Research includes patients receiving extracorporeal membrane oxygenation, with attention to argatroban and enoxaparin use and laboratory-guided anticoagulation strategies.
- ECMO anticoagulation
- Anti-IIa and anti-Xa assay guidance
- Thrombotic and bleeding risk management
The therapeutic focus is on anticoagulant selection and monitoring in critically ill patients requiring mechanical circulatory support.
