Phenol, Liquefied

This article discusses the use of Phenol, Liquefied in clinical trials, specifically its role in allergy testing solutions. The focus is on a study examining the effectiveness of immunotherapy for adults with moderate to severe allergic rhinitis or rhinoconjunctivitis caused by house dust mite allergies. The trial involves a solution for skin-prick tests that contains Phenol, Liquefied as an ingredient.

Table of Contents

What is PHENOL, LIQUEFIED?

PHENOL, LIQUEFIED is an active substance used in a medical product called “HAL Allergy Pricktest Negativkontrolle, Pricktestlösung” (which translates to “HAL Allergy Prick Test Negative Control, Prick Test Solution” in English)[1]. This product is manufactured by HAL ALLERGY B.V. and is authorized for use in Germany[1].

Phenol is a chemical compound that, when liquefied, is used in various medical applications. In this context, it serves as a key component in allergy testing solutions[1].

Uses in Allergy Testing

The primary use of PHENOL, LIQUEFIED in this product is for allergy testing, specifically in skin-prick tests. These tests are used to diagnose allergies by introducing small amounts of potential allergens into the skin and observing the reaction[1].

In the context of allergy testing, this solution serves as a negative control. A negative control is a substance that should not cause an allergic reaction in most people. It’s used as a comparison to help interpret the results of other allergen tests performed at the same time[1].

The product is classified under the ATC (Anatomical Therapeutic Chemical) code V04CL, which stands for “Tests for Allergic Diseases”[1]. This classification confirms its role in allergy diagnostics.

Administration and Dosage

The HAL Allergy Prick Test Negative Control is administered via cutaneous use, which means it’s applied directly to the skin[1]. The typical dosage is 1 drop, and it’s usually only applied once during a testing session[1].

The solution comes in a form suitable for skin-prick tests. During these tests, a small drop of the solution is placed on the skin, usually on the forearm or back, and then the skin is lightly pricked through the drop with a small, sterile probe[1].

Safety and Precautions

While PHENOL, LIQUEFIED is used in medical testing, it’s important to note that it should only be administered by healthcare professionals trained in allergy testing procedures[1]. The test should be performed in a clinical setting where any potential allergic reactions can be promptly addressed.

As with any medical procedure, patients should inform their healthcare provider about any existing medical conditions, allergies, or medications they’re taking before undergoing a skin-prick test[1].

It’s crucial to understand that while this product is used in allergy testing, it is not a treatment for allergies. Its purpose is diagnostic, helping healthcare providers identify specific allergies so that appropriate treatment plans can be developed[1].

Aspect Details
Study Type Randomized, Double-Blind, Placebo-Controlled, Multi-Centre Study
Condition Studied Moderate to Severe Allergic Rhinitis/Rhinoconjunctivitis due to House Dust Mite Allergy
Treatment PURETHAL Mites Mixture 50,000 AUeq/mL Subcutaneous Immunotherapy
Control Placebo
Primary Outcome Average daily Total Combined Rhinitis Score (TCRS) during last 8 weeks of treatment
Treatment Duration Approximately 52 weeks
Phenol, Liquefied Use Component of negative control solution in skin-prick test

Ongoing Clinical Trials on Phenol, Liquefied

  • Study on the Effectiveness of PURETHAL Mites for Adults with Moderate to Severe Allergic Rhinitis or Rhinoconjunctivitis Due to House Dust Mite Allergy

    Not recruiting

    3 1 1
    Austria Bulgaria Germany Latvia Lithuania Poland

Glossary

  • Allergic Rhinitis: An allergic reaction that causes inflammation in the nose, leading to symptoms such as sneezing, runny nose, and nasal congestion.
  • Rhinoconjunctivitis: A combination of rhinitis (nasal symptoms) and conjunctivitis (eye symptoms) often caused by allergies.
  • House Dust Mite (HDM): Tiny insects that live in household dust and are a common cause of allergies.
  • Immunotherapy: A treatment that aims to change the immune system's response to an allergen, often by gradually exposing the body to increasing amounts of the allergen.
  • Skin-Prick Test: An allergy test where small amounts of potential allergens are placed on the skin to see if they cause a reaction.
  • Phenol, Liquefied: A chemical compound used in some medical solutions, including as an ingredient in allergy testing solutions.
  • Total Combined Rhinitis Score (TCRS): A measure used to assess the severity of rhinitis symptoms and medication use in allergy studies.
  • Placebo: An inactive substance used in clinical trials to compare the effects of a treatment against no treatment.
  • Up-dosing: A phase in immunotherapy where the dose of the treatment is gradually increased to reach the maintenance dose.
  • Maintenance Phase: The period in immunotherapy where the patient receives a consistent dose of the treatment to maintain its effects.

References

  1. http://clinicaltrials.eu/trial/study-on-the-effectiveness-of-purethal-mites-for-adults-with-moderate-to-severe-allergic-rhinitis-or-rhinoconjunctivitis-due-to-house-dust-mite-allergy/