This study focuses on patients with Multiple Myeloma, a type of blood cancer that develops in plasma cells found in bone marrow. The research evaluates a new medication called ABBV-453 (also known as Surzetoclax), which will be tested either alone or in combination with other medications including Daratumumab, Pomalidomide, and Dexamethasone.
The main purpose is to understand how safe the new medication ABBV-453 is and how well patients tolerate it when used alone or combined with other multiple myeloma treatments. ABBV-453 belongs to a group of drugs called BCL-2 inhibitors, which work by blocking a protein that helps cancer cells survive.
During the study, patients will receive ABBV-453 tablets by mouth, either by itself or together with other medications that may be given as tablets or as injections under the skin. The study will monitor how patients respond to treatment and track any side effects that may occur. Doctors will regularly check patients’ blood and perform other medical tests to evaluate how well the treatment is working.



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