[11C]DASB is a radioactive tracer used in brain imaging (PET scans) to study the serotonin system. It helps researchers see how serotonin, a chemical messenger in the brain, is functioning. This tracer is particularly useful in studying changes that might occur in the early stages of Parkinson’s disease.

[11C]SB207145 is another radioactive tracer used in PET scanning that also helps visualize the serotonin system in the brain, but targets a different type of serotonin receptor. This tracer allows researchers to examine different aspects of serotonin function and how it might be affected in people who carry genetic mutations associated with Parkinson’s disease.

Parkinson’s disease – A progressive neurological disorder that affects movement and motor control. It develops when nerve cells in the brain that produce dopamine begin to die or become impaired. The condition typically starts gradually with mild symptoms that worsen over time. Common signs include tremors, particularly in the hands, slowed movement (bradykinesia), stiff muscles, impaired posture and balance, and changes in speech patterns.

Prodromal Parkinson’s disease – The early phase of Parkinson’s disease that occurs before classic motor symptoms become apparent. During this stage, individuals may experience subtle changes such as loss of smell, sleep disorders, constipation, and mild cognitive changes. This phase can last several years before the development of more recognizable movement-related symptoms. The changes occur due to early degeneration of certain brain cells and the presence of abnormal protein accumulation.