This clinical trial is focused on studying treatments for Polycystic Ovary Syndrome (PCOS), a condition that affects women’s hormone levels, often leading to irregular menstrual cycles and difficulty in getting pregnant. The study will compare two different treatments to help women with PCOS who wish to become pregnant. The first treatment involves continuing the use of letrozole, a medication taken orally in the form of a film-coated tablet. The second treatment involves switching to gonadotropins, which are hormones used to stimulate the ovaries and are administered through injections. The specific types of gonadotropins used in this study are human menopausal gonadotropins and follitropin alfa.

The purpose of the study is to determine which treatment is more effective in improving the chances of having a live birth. Participants will be randomly assigned to either continue with letrozole or switch to gonadotropins. The study will monitor the participants over a period of up to eight months to see if they become pregnant and have a live birth. During this time, the study will also look at other outcomes such as the number of pregnancies, any pregnancy complications, and the overall health and well-being of the participants.

Participants will be asked to keep a medication diary and complete questionnaires about their quality of life and mental health at different points during the study. The study will also assess the cost-effectiveness of the treatments by considering the costs involved and the quality of life of the participants. The goal is to provide valuable information that can help improve treatment options for women with PCOS who are trying to conceive.