This clinical trial is focused on studying the effects of a combination therapy for patients with autoimmune hypothyroidism, a condition where the thyroid gland does not produce enough hormones, leading to symptoms like tiredness. The study will compare the effects of a combination of two medications, levothyroxine and liothyronine, against the use of levothyroxine alone. Levothyroxine is a synthetic form of the thyroid hormone thyroxine, while liothyronine is a synthetic form of the hormone triiodothyronine. The trial will also include a group receiving a placebo, which looks like the medication but contains no active ingredients.

The purpose of the study is to investigate whether the combination of levothyroxine and liothyronine can reduce tiredness more effectively than levothyroxine alone in patients who continue to feel tired despite treatment. The study will last for one year, during which participants will receive either the combination therapy, levothyroxine alone, or a placebo. Researchers will monitor changes in tiredness and other thyroid-related symptoms, as well as overall quality of life. The study will also explore if certain genetic variations in participants affect the treatment outcomes.

Participants will be asked to take the medication orally and will have regular check-ups to assess their symptoms and any side effects. The trial aims to provide insights into whether the combination therapy offers a better treatment option for those with persistent symptoms of autoimmune hypothyroidism. The findings could help improve treatment strategies and enhance the quality of life for patients with this condition.