Trastuzumab Deruxtecan: This medication is being studied as a first-line treatment for patients with a specific type of lung cancer that cannot be removed by surgery or has spread to other parts of the body. It targets cancer cells with certain mutations in the HER2 gene, which are found in some lung cancers. The goal is to see if this medication can help stop the cancer from growing or spreading.

Platinum: This is a type of chemotherapy drug used to treat various cancers, including lung cancer. It works by damaging the DNA of cancer cells, which can stop them from growing and dividing.

Pemetrexed: This is another chemotherapy drug that is often used in combination with other medications to treat lung cancer. It works by interfering with the cancer cells’ ability to use folate, a vitamin that is necessary for cell growth.

Pembrolizumab: This medication is an immunotherapy drug that helps the body’s immune system recognize and attack cancer cells. It is used to treat several types of cancer, including lung cancer, by blocking a protein that prevents the immune system from attacking cancer cells.

Non-Small Cell Lung Cancer with HER2 exon 19 or 20 mutations – This is a type of lung cancer that is characterized by mutations in the HER2 gene, specifically in exon 19 or 20. It is classified as non-small cell, which is the most common type of lung cancer, accounting for about 85% of cases. The disease can be locally advanced, meaning it has spread to nearby tissues or lymph nodes, or metastatic, indicating it has spread to other parts of the body. The presence of HER2 mutations can influence the behavior of the cancer, potentially affecting its growth and spread. This form of cancer is considered unresectable, meaning it cannot be removed completely through surgery. The progression of the disease is typically monitored through imaging and clinical assessments to evaluate changes in tumor size and spread.