This study focuses on patients with Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs), which are rare tumors that develop in the digestive system or pancreas. The main treatment being tested is Lutetium-177 Edotreotide, a radioactive medication that specifically targets tumor cells. This treatment, also known as Peptide Receptor Radionuclide Therapy (PRRT), will be compared to standard cancer treatments to determine if it works better.
The study includes several standard cancer treatments that may be used as comparison: Everolimus, Temozolomide, Capecitabine, Oxaliplatin, and Fluorouracil. Some patients will also receive supportive medications like Calcium Folinate and an amino acid solution to protect their kidneys during treatment. The purpose is to determine if the radioactive treatment is more effective than current standard treatments for these types of tumors.
During the study, patients will be randomly assigned to receive either the radioactive treatment or one of the standard treatments. The doctors will monitor how well the treatments work by taking regular scans and checking patients’ overall health. They will also track how the treatments affect patients’ quality of life using questionnaires.



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