This study focuses on patients with Gastroenteropancreatic neuroendocrine tumors (GEP-NET), which are rare tumors that develop in the digestive system or pancreas. The study will test two treatments: Lutathera (a radioactive medicine) combined with Sandostatin LAR (a hormone-based treatment) compared to using Sandostatin LAR alone. The main purpose is to determine if the combination treatment is more effective at delaying the progression of the disease or extending survival compared to the standard treatment.
The treatment involves receiving either Lutathera infusions together with Sandostatin LAR injections, or only Sandostatin LAR injections. Lutathera contains a radioactive substance that specifically targets tumor cells. During Lutathera treatment, patients will also receive an amino acid solution called LysaKare to protect the kidneys. To manage potential side effects, patients may receive anti-nausea medications.
The study will monitor how the disease responds to treatment through regular medical examinations and imaging tests. Doctors will track any changes in tumor size and assess how patients feel during the treatment. The study will continue for several years to determine the long-term effects of both treatments.



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