Pembrolizumab is a medication that helps the immune system fight cancer. It works by blocking a specific protein on cancer cells, allowing the immune system to better recognize and attack these cells. It is used in this trial to evaluate its effectiveness in treating multiple solid tumors.

Lenvatinib is a medication that targets certain proteins involved in the growth of cancer cells. By inhibiting these proteins, lenvatinib can help slow down or stop the growth of tumors. In this trial, it is used in combination with other medications to assess its role in treating solid tumors.

Belzutifan is a medication that works by inhibiting a protein that helps cancer cells survive in low-oxygen environments. By blocking this protein, belzutifan can make it harder for cancer cells to grow and spread. This trial is testing its effectiveness when used alongside pembrolizumab and lenvatinib in treating various solid tumors.

Liver cancer – This disease involves the growth of malignant cells in the liver, which can disrupt its normal functions. It often begins as a small tumor that can grow and spread to other parts of the body. The progression can lead to symptoms such as weight loss, loss of appetite, and jaundice.

Colon cancer – This type of cancer starts in the colon or rectum, part of the digestive tract. It typically begins as small, benign clumps of cells called polyps, which can become cancerous over time. As it progresses, it may cause changes in bowel habits, blood in the stool, and abdominal discomfort.

Pancreatic cancer – This cancer originates in the tissues of the pancreas, an organ that lies behind the lower part of the stomach. It often progresses silently, with symptoms appearing only in advanced stages. These symptoms can include jaundice, weight loss, and abdominal pain.

Bile duct or gallbladder cancer – This disease affects the bile ducts or gallbladder, which are involved in the storage and transport of bile. It can cause symptoms like jaundice, abdominal pain, and nausea as it progresses. The cancer can spread to nearby organs and tissues.

Endometrial cancer – This cancer begins in the lining of the uterus, known as the endometrium. It often presents with abnormal vaginal bleeding, especially after menopause. As it progresses, it may cause pelvic pain and other symptoms.

Esophageal cancer – This type of cancer occurs in the esophagus, the tube that carries food from the throat to the stomach. It can cause difficulty swallowing, weight loss, and chest pain as it advances. The cancer may spread to nearby lymph nodes and other organs.