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Mepivacaine Hydrochloride

Clinical trials are investigating Mepivacaine Hydrochloride in different patient groups to see how well it helps with pain control and how safe it is in real procedures. The studies focus on people with obstetric perineal tears, children after orthopedic surgery, patients with ischemic stroke, people with hydrocele or spermatocele, and patients needing arterial puncture for blood gas testing.

Table of Contents

Trial overview

These studies are testing Mepivacaine Hydrochloride in different clinical situations where pain control is important.[1] The trials are mostly Phase 3 studies, with one Phase 2 study, and all are listed as Authorised.[1] The target groups include adults and children, depending on the condition being studied.[1]

Obstetric perineal lacerations

One Phase 3 trial is studying repair of obstetric perineal lacerations, which are tears in the area between the vagina and anus after childbirth.[1] The study includes 80 participants and looks at whether patient-controlled sedation with propofol, added to standard care with a pudendal nerve block, can reduce pain and discomfort during the procedure.[1] The main endpoint is pain/discomfort during the procedure.[1]

This trial lists Mepivacaine Hydrochloride among the interventions used in the study setting.[1] It also includes other drugs such as ropivacaine, lidocaine, and propofol, which shows that the study is looking at pain control in a broader care plan rather than testing only one medicine.[1]

Pain after pediatric orthopedic surgery

Another Phase 3 trial is studying persistent postoperative pain, which means pain that continues after surgery, in children after orthopedic trauma surgery.[2] The trial plans to enroll 222 participants and aims to show that locoregional analgesia, meaning pain control in a specific body area, can help prevent longer-lasting pain.[2] Mepivacaine Hydrochloride appears in the intervention list as Carbocaine, which is one of the local anesthetic options used in the study.[2]

The main endpoint is pain measured by a Numerical Rating Scale (NRS) 3 months after surgery.[2] This means the researchers are not only checking immediate pain, but also whether pain remains months later.[2]

Ischemic stroke study

The Phase 2 study called MEPI-AVC is evaluating the efficacy and safety of mepivacaine on neurological sequelae, which are health problems that remain after a stroke.[3] The condition studied is ischemic stroke, which happens when blood flow to part of the brain is blocked.[3] This trial includes 38 participants and uses a subcutaneous injection, meaning an injection under the skin.[3]

The main endpoint defines a response as improvement about 1 hour after injection compared with before injection, in at least one clinical score for language, motor skills, or visual skills.[3] In simple terms, the researchers want to know whether symptoms improve shortly after treatment in people with stroke-related problems.[3]

Hydrocele and spermatocele study

One Phase 3 trial is studying hydrocele and spermatocele, which are fluid-filled conditions around the testicle area.[4] The study plans to enroll 300 participants and compares two treatment approaches: Aetoxysclerol alone versus Aetoxysclerol combined with ethanol.[4] The study also looks at pain during treatment with different anesthesia options, including local anesthesia with Mepivacaine Hydrochloride listed as Mepivacaine Accord.[4]

The primary outcomes include symptoms on the treated side 3 months after treatment and pain during treatment measured on a 0-10 scale.[4] The trial also lists several reasons a person may not be suitable for participation, such as allergy to the study agents, language barriers that make the study hard to understand, or a hydrocele/spermatocele that cannot be drained through the skin.[4]

Pain during arterial puncture

The newest listed Phase 3 trial is testing whether infiltrated Mepivacaine Hydrochloride can reduce pain from arterial puncture during blood gas analysis.[5] This study includes 108 participants with respiratory disease or a need for blood gas testing in a pulmonology outpatient clinic.[5] The trial compares Mepivacaine Hydrochloride with placebo and with no local anesthesia at all.[5]

The main endpoint is whether pain from the puncture is reduced.[5] This makes the study especially focused on a common procedure-related pain problem in outpatient care.[5]

Endpoints and who can join

Across these trials, the main outcomes are mostly about pain relief, discomfort, symptom improvement, and response after treatment.[1][2][3][4][5] Some studies measure results right away during a procedure, while others measure outcomes weeks or months later.[1][2][4]

The people who may join depend on the study and the medical problem being treated.[1][2][3][4][5] The trials include adults after childbirth injury, children after orthopedic trauma surgery, patients with stroke-related symptoms, people with hydrocele or spermatocele, and patients needing arterial puncture for blood gas analysis.[1][2][3][4][5]

Trial ID Phase Condition studied Status Enrollment
2022-502292-39-00 Phase 3 Obstetric perineal lacerations Authorised 80
2023-503499-25-00 Phase 3 Post-operative pain after surgery in children Authorised 222
NCT05222828 Phase 2 Ischemic stroke Authorised 38
2022-502284-38-00 Phase 3 Spermatocele, Hydrocele Authorised 300
2025-522974-35-00 Phase 3 Respiratory disease; blood gas analysis need Authorised 108

FAQ

  • What are the clinical trials with Mepivacaine Hydrochloride trying to find out? They are studying whether Mepivacaine Hydrochloride helps reduce pain during or after procedures. The trials also look at safety, symptom improvement, and whether it works better than placebo or no local anesthesia.
  • Who can take part in these trials? The target groups are different in each study. They include adults with obstetric perineal lacerations, children after orthopedic trauma surgery, patients with ischemic stroke symptoms, people with hydrocele or spermatocele, and patients attending a lung clinic for arterial puncture.
  • What phases are the Mepivacaine Hydrochloride trials in? The listed trials are in Phase 2 and Phase 3. Phase 2 studies usually look at early signs of benefit, while Phase 3 studies compare treatments in larger groups.
  • What conditions are being studied? The trials cover obstetric perineal lacerations, post-operative pain after pediatric orthopedic surgery, ischemic stroke, hydrocele, spermatocele, and pain from arterial puncture during blood gas analysis.
  • What outcomes are being measured in these studies? The trials measure pain, discomfort, symptom improvement, and treatment response. Some studies also measure pain scores over time, such as right after a procedure or months later.

Ongoing Clinical Trials on Mepivacaine Hydrochloride

  • Study on the Effects of Mepivacaine Hydrochloride for Patients with Neurological Symptoms After Ischemic Stroke

    Recruiting

    1 1 1
    Investigated drugs:
    France

  • Study on Sclerotherapy for Hydrocele and Spermatocele Using Lauromacrogol 400 and Ethanol in Adult Patients

    Recruiting

    1 1 1 1
    Investigated diseases:
    Investigated drugs:
    Sweden

  • Study on Preventing Persistent Postoperative Pain in Children Using Mepivacaine Hydrochloride and Drug Combination

    Recruiting

    1 1 1 1
    Investigated drugs:
    France

  • Study on Patient-Controlled Sedation with Propofol for Women Undergoing Repair of Obstetric Perineal Tears Using Ropivacaine, Lidocaine, and Mepivacaine

    Recruiting

    1 1 1 1
    Investigated diseases:
    Investigated drugs:
    Sweden

  • Testing How Well Mepivacaine Works to Reduce Pain During Arterial Puncture in Patients with Respiratory Disease Needing Blood Gas Analysis

    Not yet recruiting

    1 1 1
    Investigated drugs:
    Spain

Glossary

  • Clinical trial: A research study in people that tests whether a treatment is safe and works for a specific problem.
  • Interventional study: A study where researchers give a treatment or procedure and then measure the results.
  • Phase 2: An early study phase that looks at whether a treatment may help and begins to check safety.
  • Phase 3: A later study phase with more participants, used to compare treatments and confirm benefits and safety.
  • Enrollment: The number of people planned to join a trial.
  • Primary outcome: The main result the researchers want to measure, such as pain relief or symptom improvement.
  • Placebo: A treatment that looks like the study drug but has no active medicine. It helps show whether the real treatment works.
  • Local anesthesia: A way to numb a small area of the body so a procedure hurts less.
  • Pudendal nerve block: A type of local pain control used in the pelvic area during repair of obstetric tears.
  • Arterial puncture: A needle stick into an artery, often done to take blood for gas analysis.
  • Numeric Rating Scale (NRS): A pain scale where people rate pain with a number, often from 0 to 10.
  • Responders: Participants who show a meaningful improvement after treatment, based on the study’s rules.

References

  1. https://clinicaltrials.gov/study/2022-502292-39-00
  2. https://clinicaltrials.gov/study/2023-503499-25-00
  3. https://clinicaltrials.eu/trial/study-on-the-effects-of-mepivacaine-hydrochloride-for-patients-with-neurological-symptoms-after-ischemic-stroke/
  4. https://clinicaltrials.gov/study/2022-502284-38-00
  5. https://clinicaltrials.gov/study/2025-522974-35-00