#1 Clinical Trials Search in Europe

Lymecycline

Clinical trials investigating Lymecycline are studying how it performs in patient groups with acne and hidradenitis suppurativa. These studies look at treatment results and compare Lymecycline with other therapies or standard care. The trials include people with moderate acne and patients with Hurley stage 2 active hidradenitis suppurativa.

Table of Contents

Clinical trials overview

The trial data show Lymecycline being studied in a Phase 3 acne trial and as a tetracycline derivative in a Phase 3 hidradenitis suppurativa study.[2][3] These are interventional studies, which means researchers are testing treatment plans in patients rather than only observing them.[2][3]

Acne trial in skin of color patients

One authorised Phase 3 trial studies patients with moderate acne and focuses on skin of color patients.[2] In this study, Lymecycline appears in the treatment options compared with other acne treatments such as doxycycline and topical therapies.[2]

The trial’s goal is to assess early treatment of moderate facial acne and compare it with the current standard of care.[2] The main result is measured with an ARP severity score based on facial pictures, and success is defined as a score below 2 at 6 months, which means no or very mild ARP.[2]

Hidradenitis suppurativa trial

Another authorised Phase 3 study looks at patients with Hurley stage 2 active hidradenitis suppurativa.[3] The trial compares a treatment plan based on antibiotics with a control treatment based on a tetracycline derivative, which is the group that includes Lymecycline in the trial data.[3]

The study aims to show that the experimental antibiotic plan works better than 12 weeks of tetracycline-derivative treatment at week 12.[3] This is a head-to-head comparison, meaning one treatment strategy is tested against another to see which gives better results.[3]

Trial status and phase

Both trials listed in the source data are authorised, which means they have been approved to proceed.[2][3] Both are also Phase 3 studies, the stage where treatments are tested in larger groups and compared with standard care or another active treatment.[2][3]

What the trials measure

In the acne study, the main endpoint is the ARP severity score at month 6, using facial photos and a validated scoring algorithm for dark skin types.[2] A patient is counted as a success if the score is below 2, which means no or very mild ARP.[2]

In the hidradenitis suppurativa study, the main endpoint is the percentage of patients who reach clinical remission at week 12, defined as a 90% improvement in the IHS4 score from baseline.[3] Baseline means the starting point before treatment begins.[3]

Who the trials are for

The acne trial includes people with moderate facial acne, and the brief summary says it focuses on skin of color patients.[2] The hidradenitis suppurativa trial includes patients with active disease at Hurley stage 2, which is a more advanced form than early stage disease.[3]

These studies are not general drug descriptions; they are specific research projects that ask whether Lymecycline or tetracycline-derivative treatment plans can help in these patient groups.[2][3]

Trial ID Phase Condition studied Status Enrollment
2023-507519-36-00 Phase 3 Acne Authorised 420
NCT05821478 Phase 3 Hurley stage 2 active Hidradenitis Suppurativa Authorised 92

FAQ

  • What are the clinical trials about Lymecycline studying? The trials are looking at Lymecycline as part of treatment plans for skin conditions, mainly acne and hidradenitis suppurativa. They compare it with other treatments or standard care to see how well it works.
  • Who can take part in these trials? The trial data mention patients with moderate acne, including skin of color patients, and patients with Hurley stage 2 active hidradenitis suppurativa. Each trial has its own entry rules.
  • What phase are the Lymecycline trials in? The trials listed are Phase 3 studies. Phase 3 trials test how well a treatment works in larger patient groups and compare it with another treatment.
  • What outcomes are the trials measuring? One acne trial measures ARP severity at 6 months. The hidradenitis suppurativa trial measures clinical remission at week 12 using the IHS4 score.
  • Are these trials still active? The trials in the data are listed as authorised. That means they have been approved to move forward.

Ongoing Clinical Trials on Lymecycline

  • Study Comparing Dalbavancin to Standard Antibiotics for Patients with Staphylococcus aureus Bloodstream Infections

    Recruiting

    1 1 1 1
    Investigated diseases:
    Investigated drugs:
    France

  • Study Comparing Isotretinoin with Doxycycline, Tretinoin, and Adapalene for Moderate Acne in Patients with Skin of Color

    Recruiting

    1 1 1 1
    Investigated drugs:
    France

  • Study on the Effectiveness of Ceftriaxone and Metronidazole Combination for Patients with Hurley Stage 2 Hidradenitis Suppurativa

    Recruiting

    1 1 1
    Investigated drugs:
    France

Glossary

  • Clinical trial: A research study in people that tests whether a treatment works and whether it is safe enough to use in the studied group.
  • Phase 3: A late stage of testing where a treatment is compared with another treatment or standard care in larger groups of patients.
  • Interventional study: A study where researchers give a treatment or compare treatments to see what happens.
  • Moderate acne: Acne that is not mild but not the most severe form. It can still affect the skin and quality of life.
  • Skin of color: A term used in the trial for patients with darker skin types.
  • Hidradenitis suppurativa: A long-term skin disease that causes painful lumps and swelling, often in areas where skin rubs together.
  • Hurley stage 2: A stage of hidradenitis suppurativa showing more advanced disease than early stage, with repeated lumps and tunnels under the skin.
  • Clinical remission: A state where the signs of disease improve a lot or are no longer seen in the study definition.
  • IHS4 score: A scoring system used in hidradenitis suppurativa trials to measure how severe the disease is.
  • ARP severity score: A score used in the acne trial to measure the severity of acne-related skin changes on the face.

References