#1 Clinical Trials Search in Europe

Glyceryl Trinitrate

Clinical trials investigating Glyceryl Trinitrate are studying how it is used in different patient groups, mainly to assess treatment effects and outcomes. The trials in this article include people with heart-related conditions, MINOCA, and esophageal food impaction, and they measure results such as symptom relief, quality of life, and need for procedures.

Table of Contents

Trial overview

The source data includes one trial that directly studies Glyceryl Trinitrate in patients with myocardial infarction with non-obstructive coronary arteries (MINOCA).[1] Other trials in the data set include products such as nitroglycerin or Nitrolingual/Nitrospray, but those are separate studies and are not the same as Glyceryl Trinitrate.[2][3]

Conditions studied

The Glyceryl Trinitrate trial in the source data is in patients with MINOCA, which means a heart attack with no major blockage in the coronary arteries.[1] The trial is designed to test a precision-medicine approach, meaning treatment based on the likely cause of the condition rather than the same treatment for everyone.[1]

Although the full trial set covers several other conditions, those studies do not list Glyceryl Trinitrate as the study drug.[2][3][4][5][6]

Who can participate

The Glyceryl Trinitrate study includes patients with MINOCA.[1] The data does not give a full list of eligibility rules, but the target group is clearly adults with this specific heart condition.[1]

Other trials in the source data include women with asymptomatic heart failure, patients with stable angina, kidney transplant patients, people with type 2 diabetes, and patients with esophageal food impaction.[2][3][4][5][6] These are different study groups and should not be confused with the Glyceryl Trinitrate trial itself.[2][3][4][5][6]

Trial phases and status

The Glyceryl Trinitrate study is a Phase 3 trial and is listed as completed.[1] Phase 3 means the study is in a later stage and is usually designed to see how well a treatment works in a larger group of people.[1]

In the wider set of trials, most studies are also Phase 3, while the esophageal food impaction study is Phase 2.[2][3][4][5][6] Status also varies, with studies listed as authorised, suspended, or completed.[1][2][3][4][5][6]

Main endpoints and outcomes

The main endpoint for the Glyceryl Trinitrate trial is angina status and quality of life measured with the Seattle Angina Questionnaire at 1-year follow-up.[1] This means the researchers want to know how patients feel, how often they have chest pain symptoms, and how the condition affects daily life.[1]

Other trials in the source data measure different outcomes, such as exercise duration, adverse events, laboratory abnormalities, heart structure, heart pumping function, vascular function, and whether a food impaction is resolved without endoscopic removal.[2][3][4][5][6] These are important because they show how clinical trials can focus on both benefits and safety.[2][3][4][5][6]

Study details by trial

The completed Glyceryl Trinitrate study is the PROMISE study, which tested a precision-medicine approach in MINOCA and followed patients for 1 year using the Seattle Angina Questionnaire.[1] Its enrollment was 145 participants, and it was a Phase 3 interventional study.[1]

Other interventional studies in the data include the TREASURE trial in subclinical heart failure, the ORESA study in stable angina, BELAFENDO in kidney transplant patients, the STENO INTEN-CT study in type 2 diabetes, and a study of nitroglycerin for esophageal food impaction.[2][3][4][5][6]

  • TREASURE trial: Phase 3, authorised, 130 people, studying subclinical heart failure and cardiac remodeling outcomes.[2]
  • ORESA study: Phase 3, suspended, 769 people, studying stable angina and exercise duration.[3]
  • BELAFENDO: Phase 3, authorised, 44 people, studying kidney transplant patients and blood vessel function.[4]
  • STENO INTEN-CT: Phase 3, authorised, 7300 people, studying type 2 diabetes and a composite cardiovascular endpoint.[5]
  • Nitroglycerin for Esophageal Food Impaction: Phase 2, authorised, 88 people, studying whether food impaction can be resolved without endoscopic removal.[6]
Trial ID Phase Condition studied Status Enrollment
2024-518724-72-00 Phase 3 Myocardial infarction with non-obstructive coronary arteries (MINOCA) Completed 145
2023-503983-17-00 Phase 2 Esophageal Food Impaction Authorised 88
NCT03789552 Phase 3 Stable Angina Pectoris Suspended 769
2022-503135-33-00 Phase 3 Subclinical heart failure Authorised 130
2022-500143-21-01 Phase 3 Type 2 diabetes Authorised 7300
2024-515577-10-00 Phase 3 Kidney transplant Authorised 44

FAQ

  • What is being studied in trials that include Glyceryl Trinitrate? The trials are looking at Glyceryl Trinitrate in different clinical settings, including heart-related conditions, MINOCA, and esophageal food impaction. They focus on treatment effects, symptom relief, and patient outcomes.
  • Who can take part in these trials? The target groups vary by study. They include patients with subclinical heart failure, stable angina, kidney transplant, type 2 diabetes, MINOCA, and esophageal food impaction.
  • What phases are the Glyceryl Trinitrate trials in? The source data shows Phase 2 and Phase 3 trials. Most of the listed studies are Phase 3, while one study on esophageal food impaction is Phase 2.
  • What outcomes are researchers measuring? Researchers measure different outcomes depending on the study. These include exercise duration, quality of life, resolution of food impaction, heart structure and function, and cardiovascular event rates.
  • Are all Glyceryl Trinitrate trials still active? No. The trial statuses are mixed. Some are authorised, one is suspended, and one is completed.

Ongoing Clinical Trials on Glyceryl Trinitrate

  • Study on the Effects of Belatacept, Ciclosporin, and Tacrolimus on Blood Vessel Health in Kidney Transplant Patients

    Recruiting

    1 1 1 1
    Investigated drugs:
    France

  • Study on Heart Health in Type 2 Diabetes Patients Using Semaglutide and Dapagliflozin Combination

    Recruiting

    1 1 1 1
    Investigated drugs:
    Denmark

  • Study on the Effects of Perindopril, Valsartan, and Glyceryl Trinitrate in Women with Asymptomatic Heart Failure

    Recruiting

    1 1 1 1
    Investigated diseases:
    Investigated drugs:
    The Netherlands

  • Study on Glyceryl Trinitrate for Treating Esophageal Food Impaction in Adults

    Recruiting

    1 1
    Investigated drugs:
    Denmark

  • Study on the Effects of T89 and Glyceryl Trinitrate for Patients with Stable Angina

    Not yet recruiting

    1 1 1
    Investigated drugs:
    Bulgaria Poland Romania Slovakia

  • Study on the Effects of Warfarin, Lysine Aspirin, and Clopidogrel in Patients with Myocardial Infarction and Non-Obstructive Coronary Arteries (MINOCA)

    Not recruiting

    1 1 1 1
    Investigated diseases:
    Investigated drugs:
    Italy

Glossary

  • Interventional study: A study where researchers give a treatment or compare treatments to see what happens.
  • Phase 2: An early clinical trial phase that looks at whether a treatment may work and checks safety in a smaller group.
  • Phase 3: A later trial phase that compares treatments in larger groups to confirm benefit and safety.
  • Enrollment: The number of people planned or included in a trial.
  • Primary outcome: The main result the researchers want to measure.
  • Quality of life: How a patient feels and functions in daily life, including comfort and well-being.
  • Ejection fraction: A measure of how well the heart pumps blood.
  • Left ventricular mass index: A measure of the size or thickness of the main pumping chamber of the heart.
  • Concentric remodeling: A change in the shape of the heart muscle, often meaning the walls are thicker relative to the chamber size.
  • Endothelium-dependent dilation: How well blood vessels widen in response to signals from the vessel lining.
  • Composite cardiovascular endpoint: A combined result that includes several heart and blood vessel events, such as heart attack, stroke, or death.
  • Endoscopic removal: A procedure using a camera tube to remove something from the body, such as food stuck in the esophagus.

References

  1. https://clinicaltrials.gov/study/2024-518724-72-00
  2. https://clinicaltrials.gov/study/2022-503135-33-00
  3. https://clinicaltrials.eu/trial/study-on-the-effects-of-t89-and-glyceryl-trinitrate-for-patients-with-stable-angina/
  4. https://clinicaltrials.gov/study/2024-515577-10-00
  5. https://clinicaltrials.gov/study/2022-500143-21-01
  6. https://clinicaltrials.gov/study/2023-503983-17-00