#1 Clinical Trials Search in Europe

Autologous Chondrocytes

Clinical trials investigating Autologous Chondrocytes are studying treatment for knee cartilage lesions. These studies look at whether the approach can improve symptoms, function, and quality of life compared with standard care. The main target group is adults with symptomatic articular cartilage damage in the knee.

Table of Contents

Trial overview

The source data describe one randomized controlled trial that studied Autologous Chondrocytes in people with a symptomatic articular cartilage lesion of the knee.[1] The trial compared IMPACT with conservative treatment and was completed.[1]

Who was studied

The target population was patients with cartilage damage in the knee, especially lesions in the femoral condyles or trochlea.[1] These are areas inside the knee joint where damaged cartilage can cause pain and problems with movement.[1]

Treatment and comparison

The study tested IMPACT, given as an intra-articular injection, meaning an injection placed directly into the joint.[1] The comparison group received conservative treatment, which in this trial meant optional physical therapy and pain medication, with no surgical treatment.[1]

Study phase and design

This was a Phase 3 study with 60 enrolled participants.[1] Phase 3 trials usually compare a treatment with standard care in a larger patient group to see how well it performs in real clinical use.[1]

The study was designed to compare clinical improvement and quality of life after randomization.[1] Randomization means patients are assigned to study groups by chance.[1]

Outcomes measured

The main study outcomes were clinical improvement and quality of life at 3, 6, and 9 months.[1] Clinical improvement means whether patients felt and functioned better after treatment.[1]

The trial measured these outcomes using KOOS subscales and EQ5D.[1] KOOS is a knee questionnaire, and EQ5D is a health and quality-of-life questionnaire.[1]

What the results track

The study focused on whether Autologous Chondrocytes-related treatment could do better than standard care for symptoms and daily-life impact in knee cartilage lesions.[1] The time points at 3, 6, and 9 months show that the researchers were looking at both short-term and medium-term results.[1]

Trial ID Phase Condition studied Status Enrollment
2024-514612-27-01 Phase 3 Symptomatic articular cartilage lesion of the knee (femoral condyles or trochlea) Completed 60

FAQ

  • What are clinical trials of Autologous Chondrocytes studying? They are studying whether treatment can improve symptoms, knee function, and quality of life in people with cartilage damage. The trial data compare this approach with standard care.
  • Who may take part in these trials? The main study population is patients with symptomatic articular cartilage lesions of the knee. The lesions are in the femoral condyles or the trochlea.
  • What phase is the trial? The trial in the source data is a Phase 3 study. Phase 3 trials usually compare a treatment with standard care in a larger group of patients.
  • What outcomes are being measured? The study measures clinical improvement and quality of life at 3, 6, and 9 months. It uses KOOS subscales and EQ5D scores to track these results.
  • What treatment is being compared in the trial? The trial compares IMPACT, given as an intra-articular injection, with conservative treatment. Conservative treatment means standard care such as optional physical therapy and pain medication, without surgery.

Ongoing Clinical Trials on Autologous Chondrocytes

  • Study on Autologous Chondrocytes and Remestemcel for Knee Cartilage Lesions in Patients with Symptomatic Articular Cartilage Damage

    Not recruiting

    1 1 1
    Investigated diseases:
    Investigated drugs:
    The Netherlands

Glossary

  • Articular cartilage: The smooth tissue that covers the ends of bones inside a joint and helps the joint move smoothly.
  • Cartilage lesion: An area of damage in the cartilage.
  • Knee: The joint between the thigh bone and the lower leg bone.
  • Femoral condyles: Rounded parts at the lower end of the thigh bone that help form the knee joint.
  • Trochlea: A groove-like part of the knee joint where the kneecap moves.
  • Randomized: Patients are placed into treatment groups by chance, not by choice.
  • Conservative treatment: Standard non-surgical care, such as physical therapy and pain medicine.
  • Intra-articular injection: An injection given directly into a joint.
  • KOOS: A questionnaire used to measure knee symptoms, function, and how the knee affects daily life.
  • EQ5D: A questionnaire used to measure general health and quality of life.
  • Quality of life: How a health problem affects a person's daily life and well-being.

References