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Apocynin

Clinical trials are investigating Apocynin in people with knee osteoarthritis. The main goal is to see whether it can help reduce knee pain and how well it works compared with placebo and standard treatment. One completed phase 2 study tested a combination treatment in adults with this condition.

Table of Contents

Trial overview

The available clinical trial data for Apocynin describe one completed study in people with knee osteoarthritis.[1]

This was a Phase 2 trial, which means the study was mainly looking at whether the treatment may help and also gathering more information about the treatment in a patient group.[1]

Study design and treatments

The trial was placebo-controlled, double-blinded, and randomized.[1]

In simple terms, participants were assigned by chance to a treatment group, and neither the participants nor the study team knew which treatment was given during the study.[1]

The study also used a dose-finding approach, meaning it was designed to explore the treatment amount being tested.[1]

The treatments compared were APPA, a matching placebo, and Panodil film-coated tablets 500 mg in a new formulation.[1]

APPA was given orally at 2400 mg in the trial.[1]

Who participated

The study enrolled 225 participants.[1]

The target population was adults with knee osteoarthritis.[1]

What the trial measured

The primary endpoint was the change from the start of the study in the WOMAC pain sub-score for the target knee at week 12.[1]

The WOMAC pain sub-score is a standard questionnaire score used to measure pain in osteoarthritis.[1]

The brief study summary says the trial aimed to evaluate the change in pain of the target knee.[1]

What these results mean for patients

This trial was designed to see whether a treatment containing Apocynin could improve knee pain in people with osteoarthritis.[1]

Because the study is listed as completed, the main focus of the available data is the study design and the outcome it planned to measure, not a full set of published results.[1]

For patients, the most important point is that the research centered on pain relief in one specific knee over a 12-week period.[1]

Trial ID Phase Condition studied Status Enrollment
2023-508791-11-00 Phase 2 Knee osteoarthritis Completed 225

FAQ

  • What is being studied in Apocynin trials? The trial is studying Apocynin as part of a combination treatment called APPA. It is being tested for knee osteoarthritis, with the main focus on pain relief in the target knee.
  • Who took part in the study? Adults with knee osteoarthritis took part in the trial. The study enrolled 225 participants.
  • What phase was the Apocynin trial? This was a Phase 2 trial. Phase 2 studies usually look at whether a treatment works and continue to collect safety and dosing information.
  • What treatments were compared? The study compared APPA, a matching placebo, and Panodil film-coated tablets 500 mg in a new formulation. The trial was randomized and double-blinded, which means people were assigned by chance and neither the participants nor the study team knew who got which treatment.
  • What result was the trial measuring? The main result was the change in knee pain from the start of the study to week 12. Pain was measured with the WOMAC pain score, which is a standard questionnaire for osteoarthritis symptoms.

Ongoing Clinical Trials on Apocynin

  • Study on Apocynin and Paeonol for Knee Osteoarthritis Pain Relief in Adults

    Not recruiting

    1 1
    Investigated drugs:
    Denmark

Glossary

  • Knee osteoarthritis: A long-term joint condition that causes pain, stiffness, and reduced movement in the knee.
  • Phase 2: A study stage that looks at whether a treatment may work and continues to check safety and dose information.
  • Randomized: Participants are assigned to a treatment group by chance, not by choice.
  • Double-blinded: Neither the participants nor the study team knows who is receiving which treatment during the trial.
  • Placebo: A treatment that looks like the study medicine but does not contain the active study drug.
  • Interventional study: A study where researchers give a treatment and then measure what happens.
  • Dose-finding trial: A study designed to explore which dose may be best for the condition being treated.
  • WOMAC pain sub-score: A standard questionnaire score used to measure pain in people with osteoarthritis.
  • Target knee: The specific knee chosen for measurement in the study.
  • Primary endpoint: The main result the study is designed to measure.

References

  1. https://clinicaltrials.gov/study/2023-508791-11-00