Masarykova Univerzita

Psychiatric and Neurodevelopmental Disorders

Psychoses and autism spectrum disorder are central areas of interest, with attention to biological factors linked to treatment response and core symptom expression.

  • Schizophrenia and psychosis
  • Autism spectrum disorder
  • Genetic polymorphisms in CYP1A2, MDR1, 5HT2A, 5HT2C, HDAC3, and HDAC4

Research activity in this domain includes pharmacogenetic and microbiome-related approaches to psychiatric symptoms and neurodevelopmental phenotypes.

Pediatric Oncology

The sponsor supports studies in progressive, recurrent, and metastatic high-risk paediatric malignancies, including immunotherapy-based strategies.

  • High-risk paediatric tumors
  • Dendritic cell-based antitumor therapy
  • Interleukin-12-producing cellular approaches

This area also includes safety-focused clinical research in children, adolescents, and young adults with advanced cancer.

Dermatologic and Rare Genetic Skin Disease

Clinical research extends to epidermolysis bullosa congenita, with emphasis on cell-based treatment concepts for severe inherited skin fragility disorders.

  • Epidermolysis bullosa
  • Mesenchymal stromal cells
  • Intradermal administration

These studies address safety and therapeutic potential in a rare disease setting with limited treatment options.

Neonatal and Perinatal Medicine

Another focus is primary apnea in preterm newborns, with interest in respiratory support outcomes and caffeine-related neonatal care.

  • Preterm newborns
  • Invasive respiratory support
  • Caffeine in neonatal treatment

Work in this field reflects a clinical interest in improving respiratory stability and early-life outcomes in vulnerable infants.

Hematology and Treatment Discontinuation Research

Studies in chronic myeloid leukemia examine treatment withdrawal after deep remission, with emphasis on maintaining disease control after tyrosine kinase inhibitor reduction.

  • Chronic myeloid leukemia
  • Deep molecular remission
  • Tyrosine kinase inhibitor discontinuation

This area is closely linked to long-term management strategies in hematologic malignancy.

Want to learn more about this study or check if you can participate? Contact us.

Matched clinical trials

  • Testing Caffeine Citrate for Reducing Breathing Support Needs in Premature Newborns with Primary Apnea

    Recruiting

    1 1 1 1
    Investigated drugs:
    Czechia
  • A study to evaluate the effect of allogeneic faecal microbiota on the core symptoms of autism spectrum disorder in children

    Not yet recruiting

    1 1
    Investigated diseases:
    Investigated drugs:
    Czechia
  • Study on Stopping Nilotinib, Imatinib, and Dasatinib in Patients with Chronic Myeloid Leukemia in Deep Remission

    Not recruiting

    1 1 1
    Czechia
  • Study on the Safety of Allogeneic Adipose Tissue-Derived Mesenchymal Stromal Cells for Patients with Epidermolysis Bullosa

    Not recruiting

    1 1
    Investigated diseases:
    Czechia
  • Study on Murcidencel for Children, Adolescents, and Young Adults with High-Risk Progressive or Recurrent Metastatic Tumors

    Not recruiting

    1 1
    Investigated diseases:
    Investigated drugs:
    Czechia
  • Study on the Safety and Effectiveness of Olanzapine for Patients with Schizophrenia

    Not recruiting

    1 1 1 1
    Investigated diseases:
    Investigated drugs:
    Czechia