Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts

Breast Cancer and Biomarker-Guided Treatment

Research activity includes early breast cancer with a focus on genomics, biomarker-guided therapy, and post-neoadjuvant treatment strategies in patients with high-risk disease.

  • Genomic profiling
  • Adjuvant systemic therapy
  • High-risk early breast cancer

The research landscape in this area centers on refining treatment selection after initial cancer therapy using molecular and clinical markers.

Colorectal Cancer and Symptom Management

Clinical research also addresses colorectal cancer, with attention to fatigue, vitamin D status, and quality of life after completion of standard cancer treatment.

  • Fatigue reduction
  • Vitamin D supplementation
  • Supportive care

This area links survivorship-focused care with metabolic and symptom-oriented interventions in patients recovering from colorectal cancer therapy.

Solid Tumors and Targeted Immunotherapy

Investments extend to progressive metastatic solid cancer, including work on targeted immunotherapy and bispecific antibody approaches for disease after established treatment options have failed.

  • Metastatic solid cancer
  • Immune-directed therapy
  • Antibody-based treatment

The therapeutic emphasis in this domain is on advanced malignancies with limited standard treatment choices.

HPV Vaccination and Preventive Immunology

Another research area involves prophylactic vaccination against human papillomavirus, with work in healthy volunteers and interest in immunogenicity and vaccine-related immune responses.

  • HPV prevention
  • Vaccine immunology
  • Healthy volunteer studies

This field reflects a preventive strategy aimed at reducing future HPV-associated disease burden.

Glioma and Neuro-Oncology Immunotherapy

Research activity also includes glioma, specifically WHO grade IV disease, with interest in peptide vaccination, neoepitope-specific T cells, and brain tumor immunotherapy.

  • High-grade glioma
  • Peptide vaccines
  • T-cell–based immunotherapy

The neuro-oncology focus is directed toward immune-based approaches for aggressive primary brain tumors.

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Matched clinical trials

  • Study on Post-Neoadjuvant Therapy for Early Breast Cancer Using Ipatasertib, Inavolisib, and Atezolizumab for Patients with High-Risk Early Breast Cancer

    Recruiting

    2 1 1 1
    Investigated diseases:
    Germany
  • Study on Vitamin D3 and Glycerol for Reducing Fatigue in Colorectal Cancer Patients with Low Vitamin D Levels After Treatment

    Not recruiting

    3 1 1
    Investigated diseases:
    Investigated drugs:
    Germany