Skip to content
Clinical Trials – home

Rare diseases

Investigational molecules

Locations

Our offerNewsroom

Not recruiting

Title: "Study comparing standard decolonization therapy alone versus combined with oral clindamycin for patients with MRSA throat carriage"

Verified siteRegistered drugNo placebo
Clinical Trials Concierge

Prefer not to search? Our Concierge searches the trials for you.

What is this trial about?

A plain-language summary of the goals, design and what participants do

This study focuses on treating people who carry Methicillin-Resistant Staphylococcus Aureus (MRSA) in their throat. MRSA is a type of bacteria that is resistant to many common antibiotics and can cause serious infections. The standard treatment includes nasal ointment containing mupirocin and body wash with chlorhexidine, which are substances used to remove bacteria from the body.

The purpose of this research is to determine if adding an oral antibiotic called clindamycin to the standard treatment works better at eliminating MRSA from the throat. During the study, some participants will receive clindamycin along with the standard treatment, while others will receive a placebo with the standard treatment.

The treatment period lasts for 10 days, during which participants take the medication by mouth. The maximum daily dose of clindamycin is 1800 mg. The effectiveness of the treatment will be checked by taking throat swabs after one month and again after six months to see if the MRSA bacteria are still present.

The research process

The trial runs in 3 steps – from screening to follow-up. Each step says what happens and what the team monitors.

  1. Step 1

    Initial treatment phase

    You will receive standard decolonization therapy, which includes mupirocin nasal ointment and chlorhexidin body wash.

    You may also receive either oral clindamycin or a placebo (inactive substance). Neither you nor the medical staff will know which one you are receiving.

    The treatment aims to eliminate MRSA (a type of bacteria) from your throat.

  2. Step 2

    First follow-up examination

    After 1 month, a throat swab will be taken to check if the MRSA bacteria are still present.

    This test involves collecting a sample from your throat using a cotton swab.

    The results of this test will help determine if the treatment has been successful.

  3. Step 3

    Long-term follow-up

    After 6 months, another throat swab will be taken.

    This final test will check if your throat remains free of MRSA bacteria.

    This examination completes your participation in the study.

Who can join the trial?

6 criteria

  • Must be 18 years of age or older
  • Must have MRSA bacteria present in the throat (MRSA stands for Methicillin-resistant Staphylococcus aureus, which is a type of bacteria resistant to common antibiotics)
  • Must have already completed one course of standard topical decolonization treatment (treatment that involves applying medication directly to the throat area to remove bacteria)
  • Can be either male or female
  • Must not belong to any vulnerable population groups (such as people who cannot make decisions for themselves)
  • Must be able to participate in a randomized clinical trial (a study where participants are randomly assigned to different treatment groups)

Who cannot join the trial?

15 criteria

  • Known allergy or severe sensitivity to clindamycin, mupirocin, or chlorhexidine
  • Current pregnancy or breastfeeding
  • Active gastrointestinal infection or severe digestive system problems
  • Use of antibiotics in the past 2 weeks
  • Severe liver disease (problems with liver function)
  • Severe kidney disease (problems with kidney function)
  • Current participation in other clinical trials
  • Unable to follow study procedures or attend follow-up visits
  • History of inflammatory bowel disease (chronic inflammation of digestive tract)
  • Presence of other serious medical conditions that could interfere with the study
  • History of severe adverse reactions to antibiotics
  • Children and adolescents under 18 years of age
  • People who cannot give informed consent
  • Active malignancy (cancer) requiring treatment
  • Immunocompromised patients (weakened immune system)
Clinical Trials Concierge

Prefer not to search? Our Concierge searches the trials for you.

Tell us about your condition – we search every trial in Europe and connect you with the right site.

We usually reply within a few days

Verified sites

All sites with verified contact details – recruitment status may not be available; ask directly

Trial locations

Where you can join this trial

Countries are shaded by recruitment status. Click a recruiting country to ask about joining there.

Not recruiting
Not finding your country?

Not sure what to do next?

Joining a clinical trial can seem overwhelming. We guide you step by step, so you know exactly what to expect and how we support you through the process.

See the full process and FAQ

Investigated drugs

  • Mupirocin

    is a topical antibiotic applied as a nasal ointment. It is used to eliminate harmful bacteria, specifically MRSA (Methicillin-resistant Staphylococcus aureus), from the nose. This medication works by stopping bacteria from growing and multiplying in the nasal passages.

  • Chlorhexidine

    is an antiseptic body wash that kills bacteria on the skin. It is used as part of the decolonization treatment to remove harmful bacteria from the body surface. This helps reduce the risk of spreading bacteria and prevents infections.

  • Clindamycin

    is an oral antibiotic taken by mouth. It works by stopping bacterial growth throughout the body. In this trial, it is being tested as an additional treatment alongside the standard decolonization therapy to see if it improves the success rate of eliminating MRSA from the throat.

What is already known about the treatment

  • Clindamycin

    An antibiotic medication administered orally that belongs to the lincosamide class of antibiotics, specifically designed to treat serious bacterial infections. It works by preventing bacteria from producing essential proteins needed for their growth and survival, effectively stopping bacterial reproduction at the molecular level. The medication is particularly effective against MRSA (Methicillin-resistant Staphylococcus aureus) infections and is commonly used in combination with other decolonization treatments, such as mupirocin nasal ointment and chlorhexidine body wash, to eliminate MRSA carriage in the throat.

  • Mupirocin

    A topical antibiotic applied as a nasal ointment that specifically targets bacterial infections in the nasal passages. It works by blocking bacterial protein synthesis, preventing the growth and spread of bacteria, particularly effective against MRSA colonization in the nasal cavity. This medication is a standard component of MRSA decolonization therapy and is typically used in conjunction with other treatments to maximize effectiveness in eliminating bacterial carriage.

  • Chlorhexidine

    An antiseptic and disinfectant solution used as a body wash that effectively eliminates various microorganisms on the skin surface. It works by disrupting bacterial cell membranes, leading to cell death and preventing bacterial colonization on the skin. This antiseptic is a crucial part of the standard decolonization protocol for MRSA carriers and is commonly used alongside other treatments to provide comprehensive antimicrobial coverage.

Investigated diseases

MRSA Throat Carriage - A condition where methicillin-resistant Staphylococcus aureus (MRSA) bacteria colonize the throat area. The bacteria can live in the throat without causing immediate symptoms, making the person a carrier. MRSA throat carriage occurs when these antibiotic-resistant bacteria establish themselves in the throat's mucous membranes. While carriers may not feel sick, they can potentially spread the bacteria to others. The condition can persist for extended periods if not addressed.
Trial detailsLast updated 2 Oct 2026
Age18+ yearsPhasePhase IIITrial ID2024-516377-69-01Estimated enrolment80 patientsSponsorRegion Hovedstaden

sourced from the EU Clinical Trials Register and site verification

Want to learn more about this trial or check if you can participate?

Clinical Trials Concierge

Prefer not to search? Our Concierge searches the trials for you.

Tell us about your condition – we search every trial in Europe and connect you with the right site.