Remimazolam is a sedative medication that in this trial is given through the nose using a special nasal spray device. It helps to make patients calm and sleepy. This medication belongs to the same family of drugs as midazolam, which is commonly used for sedation.

Lidocaine is a local anesthetic medication that numbs the area where it’s applied. In this trial, it’s sprayed into the nose before remimazolam to prevent discomfort and irritation of the nasal passages. It helps make the administration of remimazolam more comfortable for patients.

Anxiety – A mental health condition characterized by persistent feelings of worry, fear, and unease. Anxiety can manifest through both psychological and physical symptoms, including racing thoughts, restlessness, difficulty concentrating, and increased heart rate. The condition can vary in intensity from mild to severe, affecting daily activities and social interactions. Physical symptoms may include muscle tension, sweating, and shortness of breath.

Stress – A natural physical and mental response to life experiences that causes emotional or physical tension. Stress typically triggers the body’s “fight-or-flight” response, leading to various physiological changes including increased heart rate and elevated blood pressure. It can affect sleep patterns, appetite, and energy levels. The condition can be acute (short-term) or chronic (long-lasting), impacting both mental and physical well-being.