Rheinische Friedrich-Wilhelms-Universitaet Bonn
Bonn, Germany
Rare diseases
Investigational molecules
Locations
A plain-language summary of the goals, design and what participants do
This study focuses on several types of advanced solid tumors, including triple-negative breast cancer, gastric cancer, pancreatic cancer, small cell lung cancer, bladder cancer, and ovarian cancer. The purpose is to investigate how well two medications work together or separately in treating these cancers. The medications being studied are nivolumab and ipilimumab, which are drugs that help the body's immune system fight cancer cells.
The study will use two different treatment approaches. Some patients will receive nivolumab alone, while others will receive a combination of nivolumab and ipilimumab. Both medications are given through an intravenous infusion, which means they are delivered directly into a vein. The medications being tested are designed to boost the immune system's ability to detect and destroy cancer cells.
During the study, doctors will monitor how patients respond to the treatment and track any side effects that may occur. The study will look at whether tumors shrink or stop growing in response to the treatment, and how long patients survive without their cancer getting worse. This research may help develop new treatment options for patients with these types of advanced cancers.
The trial runs in 4 steps – from screening to follow-up. Each step says what happens and what the team monitors.
12 criteria
14 criteria
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Bonn, Germany
Heidelberg, Germany
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A prescription medication administered through intravenous infusion that belongs to the class of immunotherapy drugs known as checkpoint inhibitors. This medication works by blocking the PD-1 protein on immune cells, helping the body's immune system recognize and attack cancer cells more effectively. Nivolumab is currently approved and widely used in medical practice for treating various types of advanced cancers, including lung cancer, melanoma, and other solid tumors.
An immunotherapy medication given through intravenous infusion that works by targeting and blocking a protein called CTLA-4 on T cells, which helps activate the immune system to fight cancer cells. This medication is approved and established in medical practice for treating several types of advanced cancers, often used in combination with other immunotherapy drugs to enhance treatment effectiveness. Ipilimumab has shown significant results in clinical trials, particularly when combined with other immunotherapy agents for treating various solid tumors.
A type of breast cancer where cancer cells lack receptors for estrogen, progesterone, and HER2 protein. It grows and spreads more quickly than other types of breast cancer. The cancer develops in the breast tissue and can spread to nearby lymph nodes and other parts of the body.
A cancer that develops in the lining of the stomach. It begins when cells in the stomach start to grow uncontrollably and form a tumor. The cancer can grow through the stomach's wall and spread to nearby organs.
A disease where malignant cells form in the tissues of the pancreas. The cancer typically starts in the cells that line the ducts of the pancreas. It can spread to nearby blood vessels and organs.
A fast-growing type of lung cancer that develops in the tissues of the lungs. It typically starts in the bronchi, spreading quickly to other parts of the body. The cancer cells appear small and round under a microscope.
A cancer that begins in the cells lining the bladder. It typically starts in the innermost layer of the bladder wall. The cancer can grow and spread into deeper layers of the bladder wall.
A cancer that develops in the tissues of the ovaries. It begins when abnormal cells in the ovaries start to multiply uncontrollably. The disease can spread to the lining of the abdomen and to other organs.
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