Region Oestergoetland
Linkoping, Sweden
Not recruiting
Study on the Effects of Morphine Hydrochloride on Stress and Social Interaction in Healthy Volunteers
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What is this trial about?
A plain-language summary of the goals, design and what participants do
This clinical trial is focused on understanding how the medication morphine affects stress responses and social interactions in healthy individuals. Morphine is a well-known pain relief medication that belongs to a group of drugs called opioids. The study will also use a solution called 0.9% Sodium Chloride, which is commonly used in medical settings as a fluid replacement. The main goal of the study is to explore how morphine influences the brain, body, and feelings when people experience emotional distress, such as feeling rejected.
Participants in the study will receive either morphine or a placebo through an injection. The study will observe how these substances affect the participants' reactions to social situations that might cause stress or discomfort. This includes looking at changes in brain activity using a method called fMRI, which is a type of brain scan that shows how the brain is working. The study will also measure how participants feel and how their bodies respond to stress, including checking levels of certain stress-related substances in the body.
The study is designed to last for a short period, with participants attending sessions where they will receive the treatment and undergo various assessments. The findings from this study could help improve understanding of how morphine affects emotional and social responses, which might be useful for developing new treatments for stress-related conditions in the future.
The research process
The trial runs in 6 steps – from screening to follow-up. Each step says what happens and what the team monitors.
Who can join the trial?
7 criteria
- Age between 18 and 65 years old, and willing to provide informed consent.
- In good health as determined by medical history, heart test (ECG), and lab tests. Lab tests will check things like potassium, creatinine, hemoglobin, glucose, calcium, and others. The final decision will be made by the lead doctor.
- Ability to speak and understand Swedish.
- Females must have a negative urine pregnancy test at the start and during the study. Females who can become pregnant and are sexually active must agree to use a reliable method of birth control during the study.
- Willingness to have two IV lines (a way to give medicine directly into the vein) and undergo an MR scan (a type of imaging test).
- Must be right-handed, as determined by a specific test called the Edinburgh Handedness Inventory (EHI).
- Must have prior experience with medical opioids, such as having used medicines like oxycodone, morphine, hydrocodone, codeine, or dihydrocodeine at least once before.
Who cannot join the trial?
2 criteria
- Participants must be healthy volunteers. This means they should not have any significant medical conditions.
- Participants should not be part of a vulnerable population. This refers to groups who may have limited ability to give informed consent or may be at higher risk of harm.
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Investigated drugs
Morphine is a medication that is commonly used to relieve pain. In this study, it is being used to explore how it affects the body's response to stress and social interactions. Researchers are interested in understanding how morphine influences the brain, body, and feelings when a person experiences emotional distress, such as feeling rejected. By studying these effects in healthy individuals, scientists hope to learn more about how morphine works and its potential impact on emotional and social experiences.
What is already known about the treatment
Morphine – Morphine is typically administered in the form of an injection or oral tablet, and it is used to manage pain by altering the way the brain and nervous system respond to pain. In the context of current medical research, morphine is being studied for its effects on stress response and social interaction, particularly in healthy volunteers. The main therapeutic use of morphine is to relieve moderate to severe pain. At the molecular level, morphine works by binding to opioid receptors in the brain, which helps to reduce the perception of pain and can also affect emotional responses. It is classified pharmacologically as an opioid analgesic.
Investigated diseases
Healthy volunteers – Healthy volunteers are individuals who do not have the disease or condition being studied. They participate in clinical trials to provide baseline data for comparison with affected individuals. In studies, they help researchers understand the normal progression of physiological and psychological responses. Healthy volunteers are crucial for determining the effects of interventions, such as medications, on normal biological processes. Their participation helps in identifying potential side effects and understanding the body's typical reactions. They serve as a control group to ensure the accuracy and reliability of clinical research findings.
Trial detailsLast updated 2 Oct 2026
Age18+ yearsPhasePhase IITrial ID2024-517855-10-00Protocol codeMOR-STRESS-SIEstimated enrolment36 patientsSponsorLinkopings Universitet
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