This clinical trial is focused on studying the treatment of Multiple Myeloma, a type of cancer that affects plasma cells in the bone marrow. The study is investigating the effectiveness of a combination of medications, including Isatuximab (also known by its code name SAR650984), Bortezomib (Velcade®), Lenalidomide, and Dexamethasone. These medications are being tested together to see if they can improve the condition of patients who have been newly diagnosed with multiple myeloma and are not eligible for a transplant.
The purpose of the study is to determine if adding Isatuximab to the existing treatment of Bortezomib, Lenalidomide, and Dexamethasone can help prolong the time patients live without their disease getting worse, known as progression-free survival. Participants in the study will receive either the combination of all four medications or just the three medications without Isatuximab. Some participants may receive a placebo instead of Isatuximab. The study will last for a period of up to 115 weeks, during which the effects of the treatment will be closely monitored.
Throughout the study, participants will take the medications orally or through injections, depending on the specific drug. The study aims to gather information on how well the treatment works and any side effects that may occur. The results will help determine the potential benefits of this new combination therapy for patients with multiple myeloma who cannot undergo a transplant.



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