This clinical trial is focused on studying the effects of the medication cilostazol in individuals who experience migraine without aura. A migraine is a type of headache that can cause severe throbbing pain or a pulsing sensation, usually on one side of the head. The study aims to explore how cilostazol, which is taken as a tablet, affects men and women differently when they have migraines. The trial will also involve a comparison with a placebo, which looks like the real medication but does not contain any active ingredients.

Participants in the study will be given either cilostazol or a placebo to take orally. The main goal is to observe any differences in the occurrence of migraine-like attacks between those taking cilostazol and those taking the placebo. Additionally, the study will look at differences in heart rate and blood pressure, as well as any side effects that may occur during the study period. The study will help researchers understand the role of a substance in the body called cAMP, which is thought to be involved in migraines.

The trial will take place over a period of time, with participants being monitored for up to 12 hours after taking the medication. This will allow researchers to gather information on how cilostazol affects migraine symptoms and whether there are any differences between men and women in their response to the medication. The findings from this study could provide valuable insights into the treatment of migraines and help improve the understanding of how migraines work in the body.