Dupilumab is a medication being studied for its ability to help children aged 2 to under 6 years old who have uncontrolled asthma or experience frequent severe asthma attacks. The trial aims to see if this medication can reduce the number of severe asthma episodes over a year and to ensure it is safe and well-tolerated by young children.

Wheezing – Wheezing is a high-pitched whistling sound made while breathing, often associated with difficulty in breathing. It occurs when air flows through narrowed breathing tubes, typically during exhalation. This condition is commonly seen in respiratory infections, asthma, or allergic reactions. Wheezing can vary in intensity and may be accompanied by other symptoms like coughing or shortness of breath. It can be a temporary condition or a sign of a chronic respiratory issue. The frequency and severity of wheezing episodes can change over time.

Asthma – Asthma is a chronic respiratory condition characterized by inflammation and narrowing of the airways, leading to difficulty in breathing. Symptoms include wheezing, coughing, chest tightness, and shortness of breath, which can vary in severity and frequency. Asthma attacks can be triggered by allergens, exercise, cold air, or stress. The condition often begins in childhood but can occur at any age. Asthma is a long-term condition that can fluctuate, with periods of exacerbation and remission. The progression of asthma can be influenced by environmental factors and individual health conditions.