This clinical trial is focused on studying the effectiveness and safety of a treatment called AP707 for individuals experiencing chronic pain due to nerve damage from injuries or surgeries. Chronic pain is a long-lasting pain that persists for months or even years, often affecting daily life and activities. The treatment being tested, AP707, is a special spray used under the tongue, which contains an active ingredient called Adezunap. This study aims to see if AP707 can help reduce pain when used alongside other pain medications.
Participants in the study will be divided into two groups. One group will receive the AP707 treatment, while the other group will receive a placebo, which looks and smells like the real treatment but does not contain the active ingredient. The study will last for about a year, during which participants will have regular check-ups to monitor their pain levels and overall health. The goal is to determine if AP707 can effectively reduce pain and improve the quality of life for those suffering from chronic pain due to nerve damage.
Throughout the study, participants will continue to use their regular pain medications, which may include drugs like Gabapentin, Capsaicin, Imipramine, Amitriptyline, and Paracetamol. These medications are commonly used to manage pain and will be optimized for each participant. The study will also assess any changes in psychological well-being, sleep quality, and overall life satisfaction. By the end of the study, researchers hope to gather valuable information on the potential benefits of AP707 for managing chronic pain.
Austria 
Germany 
