Study on the Effect of Adrenaline, Vasopressin, and Steroids on Survival in Cardiac Arrest Patients

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What is this study about?

This clinical trial is focused on studying the effects of a combination of medications on patients experiencing a cardiac arrest, which is when the heart suddenly stops beating. The study will use a combination of three medications: adrenaline (also known as epinephrine), vasopressin (also known as argipressin), and steroids such as hydrocortisone and methylprednisolone. These medications are administered through an injection directly into the veins.

The purpose of the study is to determine if using this combination of medications can improve the chances of survival for patients 30 days after experiencing a cardiac arrest, compared to using adrenaline alone. During the study, some patients will receive the combination of medications, while others will receive only adrenaline. The study will monitor the patients’ health and survival over a period of time to gather results.

Participants in the study will be those who have experienced a cardiac arrest in a hospital setting and meet certain criteria for receiving adrenaline. The study aims to provide valuable information on whether this combination of medications can offer better outcomes for cardiac arrest patients.

1 joining the trial

Upon joining the trial, you will be informed about the study’s purpose, which is to determine if a combination of medications can improve survival after a cardiac arrest.

You will be asked to provide consent to participate in the study.

2 treatment administration

During the trial, you will receive medications through an intravenous (IV) line. This means the medications will be given directly into your bloodstream.

The medications include adrenaline, vasopressin, and steroids such as hydrocortisone and methylprednisolone.

The specific dosages and frequency of administration will be determined by the medical team based on the study protocol.

3 monitoring and follow-up

You will be closely monitored by the medical team throughout the trial to assess your response to the treatment.

The primary goal is to evaluate your survival at 30 days after the cardiac arrest event.

4 completion of the trial

The trial is expected to continue until December 27, 2029.

Your participation will contribute to understanding the effectiveness of the treatment in improving survival rates after cardiac arrest.

Who Can Join the Study?

Patients who have experienced a cardiac arrest while in the hospital. Cardiac arrest is when the heart suddenly stops beating.
Patients must meet the criteria for receiving adrenaline as per the current ERC guidelines. Adrenaline is a medication used in emergencies to help restart the heart.
Both male and female patients can participate.
Patients must be within the age range of 18 to 65 years old.

Who Cannot Join the Study?

Patients who have experienced a cardiac arrest cannot participate. A cardiac arrest is when the heart suddenly stops beating.

Where you can join this trial?

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Verified Sites

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Other Sites

Site Name	City	Country
Soedersjukhuset AB	Stockholm	Sweden
Queen Silvia Childrens Hospital – Sahlgrenska University Hospital – Vaestra Goetalandsregionen	Gothenburg	Sweden
Tjgtpqaev Au	Norrtalje	Sweden

Trial status

Country	Status	Recruitment Start
Sweden	Not yet recruiting	01.03.2025

Trial locations

Investigated drugs:

Adrenaline is a medication used in emergency situations to help restart the heart when it has stopped beating, a condition known as cardiac arrest. It works by stimulating the heart and increasing blood flow, which can help restore a normal heartbeat.

Vasopressin is a medication that helps to increase blood pressure by narrowing blood vessels. In the context of cardiac arrest, it is used to improve blood flow to vital organs, which can be crucial in helping the heart to start beating again.

Steroids are medications that can reduce inflammation and improve the body’s response to stress. In this trial, they are used alongside other medications to potentially improve the chances of survival after a cardiac arrest by supporting the body’s recovery processes.

Investigated diseases:

Cardiac arrest

Cardiac arrest – Cardiac arrest is a sudden loss of heart function, leading to a stop in effective blood circulation. It occurs when the heart’s electrical system malfunctions, causing an irregular heartbeat or arrhythmia. This disruption prevents the heart from pumping blood to the brain, lungs, and other organs. Without immediate intervention, the lack of blood flow can lead to unconsciousness and cessation of breathing. The condition progresses rapidly, requiring urgent medical attention to restore normal heart rhythm. It is distinct from a heart attack, which is caused by a blockage that stops blood flow to the heart muscle.

Trial ID:

2025-521283-35-00

NCT ID:

NCT05139849

Trial Phase:

Therapeutic confirmatory (Phase III)

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Study on the Effect of Adrenaline, Vasopressin, and Steroids on Survival in Cardiac Arrest Patients

What is this study about?

Who Can Join the Study?

Who Cannot Join the Study?