This clinical trial focuses on patients with advanced chronic kidney disease who have undergone a kidney transplant. The study aims to explore two different treatment approaches to prevent cytomegalovirus (CMV) infection, a common virus that can cause complications after a transplant. The treatments being studied include a combination of tacrolimus and MTOR inhibitors with anticipatory therapy, compared to tacrolimus and mycophenolic acid with universal prophylaxis. The goal is to determine which approach is more effective in preventing CMV infection in patients at high risk after their transplant.
Participants in the study will receive one of the two treatment combinations. The first group will take tacrolimus and MTOR inhibitors, while the second group will take tacrolimus and mycophenolic acid. Both groups will be monitored for their immune response to CMV before the transplant and at 15, 30, and 90 days after the transplant. The study will also track the presence of CMV infection or disease six months after the transplant to evaluate the effectiveness of each treatment approach.
The study will last until the end of 2026, with recruitment starting in mid-2025. Participants will be closely monitored throughout the study to ensure their safety and to gather data on the effectiveness of the treatments. The findings from this study could help improve the management of CMV infection in kidney transplant recipients, potentially leading to better outcomes for patients with advanced chronic kidney disease.



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