Orforglipron is an oral medication being studied to see if it can help reduce the risk of major heart-related problems in people who already have heart disease or kidney disease.

Chronic Kidney Disease – This condition occurs when the kidneys gradually lose their ability to filter waste products from the blood. As the disease progresses, the kidneys become less efficient at maintaining the body’s fluid and chemical balance. This decline can lead to an accumulation of harmful substances in the body. The damage often develops slowly over many years.

Atherosclerosis Cardiovascular Disease – This condition involves the buildup of fats, cholesterol, and other substances in and on the artery walls. These deposits, known as plaques, cause the arteries to narrow and harden over time. As the arteries become more restricted, blood flow to vital organs and tissues is reduced. This process can eventually lead to serious complications involving the heart or brain.