Spironolactone
A medication that belongs to a group of drugs called aldosterone antagonists. It helps manage heart failure by blocking a hormone called aldosterone, which can help reduce fluid retention and improve heart function. It’s commonly used to treat heart failure and high blood pressure.

Eplerenone
Similar to spironolactone, this medication is also an aldosterone antagonist. It works by blocking hormones that can cause salt and fluid retention in the body. It’s used to treat heart failure and high blood pressure, but may have fewer side effects compared to spironolactone.

Standard of care
This refers to the usual treatment that patients with heart failure with preserved ejection fraction (HFpEF) receive, which may include various medications and lifestyle modifications based on current medical guidelines.

Heart Failure with Preserved Ejection Fraction – A type of heart failure where the heart muscle contracts normally but doesn’t relax properly between beats, reducing the amount of blood that can fill the heart chambers. The heart’s pumping function remains normal, with an ejection fraction of 50% or higher, but it becomes stiff and less able to fill with blood during the relaxation phase. This condition typically develops gradually and becomes more common with age. Patients may experience symptoms such as shortness of breath, fatigue, and swelling in the legs. The condition often occurs alongside other health issues like high blood pressure, diabetes, or obesity.