This clinical trial is focused on preventing heart disease in people who have a high genetic risk for developing it. The study will use medications called statins, which are commonly used to lower cholesterol levels in the blood. The specific statins being studied are rosuvastatin and atorvastatin. These medications work by blocking a substance your body needs to make cholesterol, which can help prevent heart disease.

The purpose of the study is to see if taking statins can reduce the risk of heart-related problems and death in people with a high genetic risk for heart disease. Participants in the study will be randomly assigned to receive either a statin or a placebo. The study will last for about five years, during which time participants will take the medication daily and have regular check-ups to monitor their health and any side effects.

Throughout the study, researchers will look at how well the statins work in preventing major heart problems, such as heart attacks and strokes. They will also monitor other health factors like cholesterol levels, blood pressure, and overall health. The study aims to provide valuable information on whether using statins based on genetic risk can be an effective way to prevent heart disease.